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Centers of Excellence

Age-related Macular Degeneration


Harvard Medical School Department of Ophthalmology

Patricia A. D'Amore, Ph.D., MBA
Ivana K. Kim, M.D.

Age-related macular degeneration (AMD) occurs in neovascular ("wet" or exudative) and nonneovascular ("dry" or nonexudative) forms, and according to the World Health Organization, it is the leading cause of blindness in developed countries and ranks third worldwide after cataract and glaucomaInvestigators in the AMD Center of Excellence made numerous groundbreaking contributions to the understanding and treatment of AMD. They pioneered the pharmacologic treatment of AMD with the development of verteporfin photodynamic therapy (Visudyne). They also identified the role of vascular endothelial growth factor (VEGF) in vascular eye disease, forming the scientific basis of current anti-VEGF therapies for neovascular AMD, diabetic macular edema, and macular edema following retinal vein occlusion (RVO). Our researchers are currently working to advance the diagnosis, prevention, and treatment of AMD; they are investigating the risk factors (genetic and environmental) that predispose individuals to the disease, and are working to define the underlying pathophysiology with a goal of developing novel approaches to diagnosis and therapy.

Image: Advanced atrophic AMD or geographic atrophy (left), advanced neovascular AMD (middle), and end-stage AMD with disciform scarring (right). From: Miller J. Am J Ophthalmol. 2013 Jan;155(1):1-35.e13.

Centers of Excellence


Third International Symposium on AMD

Friday, October 24, 8am – Saturday, October 25, 2014, 6pm

View details on the HMS Department of Ophthalmology Calendar >>

Third International Biennial Symposium on AMD website >>

AMD Investigators

Alexandra R. Bowers, Ph.D.
Dong Feng Chen, M.D., Ph.D.
Jason I. Comander, MD, PhD
Kip Connor, Ph.D.
Patricia A D'Amore, PhD, MBA
Francois C. Delori, Ph.D.
Dean Eliott, M.D.
Evangelos S. Gragoudas, M.D.
Meredith S. Gregory-Ksander, Ph.D.
Neena B. Haider, Ph.D.
Deeba Husain, M.D.
Andrius Kazlauskas, Ph.D.
Ivana K. Kim, M.D.
Leo A. Kim, M.D., Ph.D.
Bruce R. Ksander, Ph.D.
Kameran Lashkari, M.D.
Qin Liu, M.D., Ph.D.
John I. Loewenstein, M.D.
Mara Lorenzi, M.D.
Richard H. Masland, Ph.D.
Joan W. Miller, M.D.
Eric Yin-Shan Ng, Ph.D.
Eli Peli, O.D., M.Sc.
Eric A. Pierce, M.D., Ph.D.
Magali Saint-Geniez, Ph.D.
Lucia Sobrin, M.D., MPH
Joan E. Stein-Streilein, Ph.D.
Luk H. Vandenberghe, Ph.D.
Demetrios G. Vavvas, MD, PhD
Russell L. Woods, Ph.D.
David M. Wu, M.D., Ph.D.
Lucy H.Y. Young, MD, PhD
Michael J. Young, Ph.D.