Research Summary

Research Summary

Dr. Vasanth’s research focuses on understanding the molecular basis of pathogenesis of multiple human genetic disorders with in vitro and in vivo models. Currently, he aims to decipher the aberrant DNA damage response and repair mechanisms that plays a role in the progressive loss of corneal endothelial cells leading Fuchs Endothelial Corneal Dystrophy (FECD).

Selected Publications

For a full publication list, please see his CV.

Allen O. Ehgrari, Shivakumar Vasanth, Jiangxia Wang, Farnoosh Vahedi, S. Amer Riazuddin, and John D. Gottsch. CTG18.1 expansion in TCF4 increases likelihood of transplantation in Fuchs Corneal Dystrophy. Cornea. 2017 Jan;36(1):40-43

Shahid Y. Khan, Shivakumar Vasanth, Firoz Kabir, John D. Gottsch, Arif O. Khan, Raghothama Chaerkady, Mei-Chong W. Lee, Carmen C. Leitch, Zhiwei Ma, Julie Laux, Rafael Villasmil, Shaheen N. Khan, Sheikh Riazuddin, Javed Akram, Robert N. Cole, C. Conover Talbot, Nader Pourmand, Norann A. Zaghloul, J. Fielding Hejtmancik, and S. Amer Riazuddin. FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1. Nature Communications. 7, Article number: 10953; 06 April 2016.

Shivakumar Vasanth, Allen O. Ehgrari, Briana C. Gapsis, Jiangxia Wang, Nicholas F. Haller, Walter J. Stark, Nicholas Katsanis, S. Amer Riazuddin, and John D. Gottsch. Expansion of CTG18.1 trinucleotide repeat in TCF4 is a potent driver of Fuchs Corneal Dystrophy. Investigative Ophthalmology and Visual Science. 2015 Jul; 56(8): 4531-6

Claudia M.B. Carvalho*, Shivakumar Vasanth*, Marwan Shinawi, Melissa B. Ramocki, Chester W. Brown, Jesper Graakjaer, Anne-Bine Skytte, Angela M. Vianna-Morgante, Ana C. V. Krepischi, Carolyn Bay, Gayle Simpson, La Donna Immken, Aleck Kyrieckos, Cynthia Lim, Sau Wai Cheung, Carla Rosenberg, Nicholas Katsanis, and James R. Lupski. Dosage changes of a segment at 17p13.1 leads to intellectual disability and microcephaly due to complex genetic interaction of multiple genes. American Journal of Human Genetics. 2014, Nov 6; 95(5): 565-578

Edwin C. Oh, Shivakumar Vasanth and Nicholas Katsanis. Metabolic regulation and energy homeostasis through the primary cilium. Cell Metabolism. 2015 Jan 6; 21(1):21-31

View a complete list of publications at>>



1998: B.Sc., Biochemistry, University of Madras, India

2000: M.Sc., Biotechnology, Pondicherry University, India

2007: Ph.D., Cell and Molecular Biology, Kent State University

Postgraduate training

2011: Postdoctoral Fellowship, National Institute of Environmental Health Sciences, National Institutes of Health

2014: Postdoctoral Fellowship, Center for Human Disease Modeling, Duke University

2015: Postdoctoral Fellowship, Department of Ophthalmology, Johns Hopkins University


2005: Joint Third Prize in the category of Pfizer Predoctoral Awards for Excellence in Renal Research at Experimental Biology meeting, San Diego, CA

2015: National Eye Institute Travel Grant, 2015 ARVO Annual Meeting

2016-2017: Co-principal Investigator, Eversight Vision Research Grant