Research Summary

Research Summary

Dr. Tecilazich’s research aims to identify the mechanisms efficient in the repair of microvessels in diabetes. This interest developed during his clinical training in Endocrinology-Metabolism when he became intrigued by the observation that often the onset and evolution of diabetic complications could not be predicted by the known risk factors (glycemic control, co-morbidities, and other clinically measurable variables). He started to develop the hypothesis that patients carried hidden contributors to a “favorable” or “unfavorable” milieu. The possibility of identifying, measuring, and potentially modifying such contributors could permit the development biomarkers of risk, as well as targets for new drugs.

Currently, his research projects are geared toward understanding the mechanism through which a discrete subpopulation of circulating monocytes, known as “patrollers,” protects retinal microvessels in diabetes. The data that he has generated with Dr. Mara Lorenzi strongly support the concept that patrollers may be an endogenous system that delivers protection and healing to the endothelium, and suggest that these beneficial activities are delivered during leukostasis – a phenomenon observed in the retinal vessels of rodents after short duration of diabetes, and characterized by an increased number of white blood cells firmly adherent to the vascular endothelium. Their data now propose the next question: how to patrollers exert protection.

Selected Publications

Tellechea A, Leal EC, Kafanas A, Auster ME, Kuchibhotla S, Ostrovsky Y, Tecilazich F, Baltzis D, Zheng Y, Carvalho E, Zabolotny JM, Weng Z, Petra A, Patel A, Panagiotidou S, Pradhan-Nabzdyk L, Theoharides TC, Veves A. Mast Cells Regulate Wound Healing in Diabetes. Diabetes. 2016 Jul;65(7):2006-19.

Tecilazich F, Feke GT, Mazzantini S, Sobrin L, Lorenzi M. Defective Myogenic Response of Retinal Vessels Is Associated With Accelerated Onset of Retinopathy in Type 1 Diabetic Individuals. Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1523-9.

Tecilazich F, Dinh T, Pradhan-Nabzdyk L, Leal E, Tellechea A, Kafanas A, Gnardellis C, Magargee ML, Dejam A, Toxavidis V, Tigges JC, Carvalho E, Lyons TE, Veves A. Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. PLoS One. 2013;8(12):e83314.

Tecilazich F, Dinh T, Lyons T. E, Julie G, Villafuerte R, Sampanis C, Charalambos G, Chun Z,Veves  A.  Mitochondrial Dysfunction  in  Diabetic  Patients  With  Neuropathy  and  Peripheral Arterial Disease. J Vasc Surg 2013;57:997-1005

Tecilazich F,* Dinh T,* Kafanas A, Doupis J, Gnardellis C. Leal EC, Tellechea A, Pradhan L, Lyons  TE,  Giurini JM,  Veves  A.  Mechanisms Involved in the  Development and Healing of Diabetic Foot  Ulceration. Diabetes. 2012  Nov;  61(11):2937-47 *equal contribution as  first authors

Biosketch

Education

2003: MD, University of Trieste Medical School, Italy

2017 (expected): PhD, University of Trieste Medical School, Italy

Postgraduate Training

2003-2008: Resident, Endocrinology and Metabolic Diseases, University of Verona, Italy

2008-2009: Clinical Specialist, Endocrinology and Metabolic Diseases, University of Verona, Italy

2009-2012: Research Fellow, Microcirculation Laboratory and Joslin-Beth Israel Deaconess Foot Center, Harvard Medical School

2012-2015: Senior Research Fellow, Schepens Eye Research Institute of Mass. Eye and Ear, Harvard Medical School

Honors

2011: Young Investigator Travel Grant Award, American Diabetes Association