Dr. Tecilazich’s research aims to identify the mechanisms efficient in the repair of microvessels in diabetes. This interest developed during his clinical training in Endocrinology-Metabolism when he became intrigued by the observation that often the onset and evolution of diabetic complications could not be predicted by the known risk factors (glycemic control, co-morbidities, and other clinically measurable variables). He started to develop the hypothesis that patients carried hidden contributors to a “favorable” or “unfavorable” milieu. The possibility of identifying, measuring, and potentially modifying such contributors could permit the development biomarkers of risk, as well as targets for new drugs.
Currently, his research projects are geared toward understanding the mechanism through which a discrete subpopulation of circulating monocytes, known as “patrollers,” protects retinal microvessels in diabetes. The data that he has generated with Dr. Mara Lorenzi strongly support the concept that patrollers may be an endogenous system that delivers protection and healing to the endothelium, and suggest that these beneficial activities are delivered during leukostasis – a phenomenon observed in the retinal vessels of rodents after short duration of diabetes, and characterized by an increased number of white blood cells firmly adherent to the vascular endothelium. Their data now propose the next question: how to patrollers exert protection.
Tellechea A, Leal EC, Kafanas A, Auster ME, Kuchibhotla S, Ostrovsky Y, Tecilazich F, Baltzis D, Zheng Y, Carvalho E, Zabolotny JM, Weng Z, Petra A, Patel A, Panagiotidou S, Pradhan-Nabzdyk L, Theoharides TC, Veves A. Mast Cells Regulate Wound Healing in Diabetes. Diabetes. 2016 Jul;65(7):2006-19.
Tecilazich F, Feke GT, Mazzantini S, Sobrin L, Lorenzi M. Defective Myogenic Response of Retinal Vessels Is Associated With Accelerated Onset of Retinopathy in Type 1 Diabetic Individuals. Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1523-9.
Tecilazich F, Dinh T, Pradhan-Nabzdyk L, Leal E, Tellechea A, Kafanas A, Gnardellis C, Magargee ML, Dejam A, Toxavidis V, Tigges JC, Carvalho E, Lyons TE, Veves A. Role of endothelial progenitor cells and inflammatory cytokines in healing of diabetic foot ulcers. PLoS One. 2013;8(12):e83314.
Tecilazich F, Dinh T, Lyons T. E, Julie G, Villafuerte R, Sampanis C, Charalambos G, Chun Z,Veves A. Mitochondrial Dysfunction in Diabetic Patients With Neuropathy and Peripheral Arterial Disease. J Vasc Surg 2013;57:997-1005
Tecilazich F,* Dinh T,* Kafanas A, Doupis J, Gnardellis C. Leal EC, Tellechea A, Pradhan L, Lyons TE, Giurini JM, Veves A. Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration. Diabetes. 2012 Nov; 61(11):2937-47 *equal contribution as first authors