Research Area Affiliations
Ahmad R. Sedaghat, M.D., Ph.D., is a fellowship-trained rhinologist with clinical and research interests in chronic rhinosinusitis (CRS). CRS is a disease that not only causes significant quality of life detriments for affected patients, but it also imposes significant costs for the health care system. It is also a disease that is based on clinical criteria; however, there are likely many different pathologic inflammatory mechanisms that converge upon the phenotype of chronic sinonasal inflammation. Thus, CRS is likely a heterogeneous disease, consisting of many different pathophysiologies. In the past, CRS has been categorized according to the presence of nasal polyps. Subsequent immunologic characterization has shown that in most cases, CRS without nasal polyps is mediated primarily by Th1 inflammation, while CRS with nasal polyps is mediated primarily by Th2 inflammation. Allergic rhinitis, mediated by type I hypersensitivity to aeroallergens, is often associated with CRS as well. However, in all cases, there is a complex interplay of different inflammatory mediators. The clinical finding that CRS patients respond variably to therapeutic interventions is likely related to the heterogeneity of disease processes involved in CRS. Dr. Sedaghat currently leads two multi-center studies focused on gaining a better understanding of the different pathologic, immunologic mechanisms that underlie CRS and, in particular, understanding the role of allergy in CRS pathophysiology. Multidisciplinary approaches, utilizing experimental and computational methodologies are used to understand the complex immunologic mechanisms that mediate CRS. The ultimate goal of these studies is to translate laboratory findings to the clinical outcomes of patients with CRS in order to develop more effective, targeted therapeutics.
Risk factors for development of chronic rhinosinusitis in patients with allergic rhinitis.
AR Sedaghat, ST Gray, CO Wilke, DS Caradonna. Int Forum Allergy Rhinol. 2012 Sep-Oct;2(5):370-5.
Atopy and chronic rhinosinusitis in children with allergic rhinitis.
2013. A.R. Sedaghat, W. Phipatanakul, and M.J. Cunningham. J Allergy Clin Immunol Pract. 1(6): 689-91.
Sinonasal variants and asthma are associated with faster development of chronic rhinosinusitis in patients with allergic rhinitis.
A.R. Sedaghat, S.T. Gray, K. Chambers, C.O. Wilke, and D.S. Caradonna. 2013. Int Forum Allergy Rhinol. 3(9):755-61.
Prevalence of and Associations with Allergic Rhinitis in Children with Chronic Rhinosinusitis
. A.R. Sedaghat, W. Phipatanakul, and M.J. Cunningham. 2014. Int J Pediatr Otorhinolaryngol. 78(2):343-7.
Clustering of chronic rhinosinusitis symptomatology reveals novel associations with objective clinicodemographic characteristics
. A.R. Sedaghat, S.T. Gray, S.D. Caradonna and D.S. Caradonna. 2015. Am J Rhinol Allergy. 29(2):100-5.
Characterization of aeroallergen sensitivities in children with allergic rhinitis and chronic rhinosinusitis
. A.R. Sedaghat, W. Phipatanakul, and M.J. Cunningham. 2014. Allergy Rhinol. 5(3):143-5.
Characterization of tree allergy prevalence in children under four years of age
. A.R. Sedaghat, W.J. Sheehan, A. Bharmanee, K. Harris, and W. Phipatanakul. 2014. Ann Allergy Asthma Immunol. 112(4):388-9.
Radiographic density profiles link frontal and anterior ethmoid sinuses behavior in chronic rhinosinusitis
. A.R. Sedaghat and N. Bhattacharyya. 2012. Int Forum Allergy Rhinol. 2(6):496-500.
Does balloon catheter sinuplasty have a role in the surgical management of pediatric sinus disease?
A.R. Sedaghat and M.J. Cunningham. 2011. Laryngoscope. 121(10):2053-4.
Clinical assessment is an accurate predictor of which patients will need septoplasty
. A.R. Sedaghat, N.Y. Busaba, M.J. Cunningham, and D.A. Kieff. 2013. Laryngoscope. 123(1):48-52.
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