About My Research
Dr. Adrian Priesol’s research involves applying vestibular perceptual testing to central and peripheral vestibular disorders. He has studied vestibular migraines and has shown that perceptual thresholds (i.e. the smallest motion that can be detected reliably) are reduced in patients with vestibular migraines but not in subjects with only migraine headaches. The reduced thresholds were most pronounced at mid frequencies, indicating abnormal integration of vertical canal and otolith signals in patients with vestibular migraine.
More recent studies of vestibular perceptual thresholds in patients with idiopathic bilateral vestibulopathy demonstrated relative sparing of otolith and vertical canal function despite the severe loss of horizontal canal function that defines this condition.
- Self-motion perception is sensitized in vestibular migraine: pathophysiologic and clinical implications. Sci Rep. 2019 10 04; 9(1):14323.
- The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds. J Assoc Res Otolaryngol. 2017 Aug; 18(4):581-590.
- The clinical manifestations of vestibular migraine: A review. Auris Nasus Larynx. 2017 Jun; 44(3):249-252.
- Clinical vestibular testing assessed with machine-learning algorithms. JAMA Otolaryngol Head Neck Surg. 2015 Apr; 141(4):364-72.
- Central Integration of Canal and Otolith Signals is Abnormal in Vestibular Migraine. Front Neurol. 2014; 5:233.
- Motion Perception in Patients with Idiopathic Bilateral Vestibular Hypofunction. Otolaryngol Head Neck Surg. 2014 06; 150(6):1040-2.
- Vestibular labyrinth contributions to human whole-body motion discrimination. J Neurosci. 2012 Sep 26; 32(39):13537-42.
- Abnormal motion perception in vestibular migraine. Laryngoscope. 2011 May; 121(5):1124-5.
- Dynamic tilt thresholds are reduced in vestibular migraine. J Vestib Res. 2011; 21(6):323-30.
- Potential solutions to several vestibular challenges facing clinicians. J Vestib Res. 2010; 20(1):71-7.
- Asymmetric responses to rotation at high frequencies in central vestibular neurons of the alert cat. Brain Res. 2004 Apr 16; 1005(1-2):137-53.
- Frequency-dependent effects of glutamate antagonists on the vestibulo-ocular reflex of the cat. Brain Res. 2000 Feb 28; 857(1-2):252-64.
Show More
Show Less
