Roberto Pineda II,
MD
Massachusetts Eye and Ear
Thomas Y. and Clara W. Butler Chair in Ophthalmology
Assistant Scientist
Harvard Medical School
Associate Professor of Ophthalmology
About My Research
Center/Research Area Affiliation
Biography
Dr. Pineda's main areas of focus are the cornea, refractive surgery (laser vision correction),and complex cataract surgery. He was the first faculty member at Mass. Eye and Ear to use clear cornea incision techniques, topical and intracameral anesthesia, and limbal relaxing incisions during cataract surgery. He has brought new techniques and technology to Mass. Eye and Ear and the New England region, including conductive keratoplasty; lntacs with lntralase for keratoconus; and DLEK, DSEK, and DALK (novellamellar corneal transplantation). He also established two longitudinal clinical sites to evaluate the viability of the Boston Keratoprosthesis in Ethiopia and Sudan. Currently, he is working on a Brillouin confocal microscope for the cornea and lens to analyze their physiologic properties.
Education
1984: BS, University of Minnesota, Twin City Campus
1985: Recipient of the International Reciprocal Student Exchange Scholarship, Univeristi Sains Malaysia, Penang, Malaysia
1990: M.D., University of Minnesota School of Medicine
Postgraduate Training
1990: Research Fellowship, Howard Hughes Medical Institute-NIH Research Scholars’ Program, National Eye Institute, National Institutes of Health
1991: PGY-1, Transitional Program, Hennepin County Medical Center, Minneapolis, MN
1994: Residency, Ophthalmology, Harvard Medical School
1996: Clinical Fellowship, Cornea and External Disease, Massachusetts Eye and Ear
Academic Appointments
1995: Chief Resident, Harvard Medical School Department of Ophthalmology
2012-present: Associate Professor of Ophthalmology, Harvard Medical School
2010-2014: Adjunct Clinical Faculty Member, New England College of Optometry
2002-2006: Scholar, The Academy at Harvard Medical School
1999-2012: Assistant Professor of Ophthalmology, Harvard Medical School
1994-1999: Instructor in Ophthalmology, Harvard Medical School
Publications powered by Harvard Catalyst Profiles
- Double trouble in DMEK surgery: Learning experience and review of the literature. Eur J Ophthalmol. 2024 Feb 22; 11206721241228346.
- New keratoconus staging system based on OCT. J Cataract Refract Surg. 2023 11 01; 49(11):1098-1105.
- Steroid Response Following Dropless Cataract Surgery Using Subconjunctival Triamcinolone. Clin Ophthalmol. 2023; 17:2803-2814.
- Case 14-2023: A Man with Redness of the Right Eye. Reply. N Engl J Med. 2023 Jul 27; 389(4):383-384.
- Video-based surgical curriculum for open-globe injury repair, VI: other trauma sequelae. Digit J Ophthalmol. 2023; 29(2):20-25.
- Case 14-2023: A 31-Year-Old Man with Redness of the Right Eye. N Engl J Med. 2023 May 11; 388(19):1800-1810.
- Non-Healing Corneal Ulcer and Uveitis Following Monkeypox Disease: Diagnostic and Therapeutic Challenges. Ocul Immunol Inflamm. 2024 Apr; 32(3):253-258.
- Conforming to the anatomy and not the standard: A technique of eccentric capsulorrhexis and intraocular lens haptic amputation for eyes with iris coloboma. Eur J Ophthalmol. 2023 Jul; 33(4):1740-1745.
- Cataract surgery in patients with underlying keratoconus: focused review. J Cataract Refract Surg. 2023 01 01; 49(1):97-102.
- Monkeypox Virus and Ophthalmology-A Primer on the 2022 Monkeypox Outbreak and Monkeypox-Related Ophthalmic Disease. JAMA Ophthalmol. 2023 01 01; 141(1):78-83.
- Incidence and risk factors for glaucoma development and progression after corneal transplantation. Eye (Lond). 2023 07; 37(10):2117-2125.
- Ocular Monkeypox - United States, July-September 2022. MMWR Morb Mortal Wkly Rep. 2022 Oct 21; 71(42):1343-1347.
- Intraoperative aberrometry: an update on applications and outcomes. Curr Opin Ophthalmol. 2023 Jan 01; 34(1):48-57.
- Anterior segment reconstruction due to cosmetic iris implants placed in the anterior chamber. J Cataract Refract Surg. 2022 08 01; 48(8):974.
- Long-Term Outcomes of Big Bubble Deep Anterior Lamellar Keratoplasty in Mucopolysaccharidoses: A Retrospective Case Series and Review of the Literature. Cornea. 2022 Jul 01; 41(7):809-814.
- Reply to Comment on: Mucopolysaccharidosis type I associated corneal disease: A clinicopathologic study. Am J Ophthalmol. 2022 03; 235:334-335.
- The Prevalence of Autoimmune Diseases in Patients with Primary Open-Angle Glaucoma Undergoing Ophthalmic Surgeries. Ophthalmol Glaucoma. 2022 Mar-Apr; 5(2):128-136.
- Seeing through the evidence for corneal neurotization. Curr Opin Otolaryngol Head Neck Surg. 2021 Aug 01; 29(4):252-258.
- Corneal and Facial Sensory Neurotization in Trigeminal Anesthesia. Facial Plast Surg Clin North Am. 2021 Aug; 29(3):459-470.
- Acute Benign Paroxysmal Positional Vertigo After Endothelial Keratoplasty-A Unique Cause of Postoperative Nausea and Headache. Cornea. 2021 Jul 01; 40(7):926-929.
- Pilot Study of Corneal Clearance With the Use of a Rho-Kinase Inhibitor After Descemetorhexis Without Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy. Cornea. 2021 Jul 01; 40(7):899-902.
- Mucopolysaccharidosis Type I-Associated Corneal Disease: A Clinicopathologic Study. Am J Ophthalmol. 2021 11; 231:39-47.
- Biomechanical Testing of Flanged Polypropylene Sutures in Scleral Fixation. Am J Ophthalmol. 2021 10; 230:134-142.
- A Biomechanical Study of Flanged Intrascleral Haptic Fixation of Three-Piece Intraocular Lenses. Am J Ophthalmol. 2021 07; 227:45-52.
- Spontaneously Regressed Corneal Intrastromal Cyst. Ophthalmology. 2020 10; 127(10):1383.
- Survival of the fittest: phacoemulsification outcomes in four corneal transplants by Dr Ramon Castroviejo. Br J Ophthalmol. 2021 08; 105(8):1076-1081.
- Regenerative medicine in Fuchs' endothelial corneal dystrophy. Taiwan J Ophthalmol. 2021 Apr-Jun; 11(2):122-131.
- Learning Descemet Membrane Endothelial Keratoplasty: A Survey of U.S. Corneal Surgeons. Cornea. 2020 May; 39(5):590-593.
- Brillouin Microscopy Visualizes Centralized Corneal Edema in Fuchs Endothelial Dystrophy. Cornea. 2020 Feb; 39(2):168-171.
- Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery. PLoS One. 2019; 14(11):e0224981.
- Corneal Tomography Changes and Refractive Outcomes After Descemet Stripping Without Endothelial Keratoplasty. Cornea. 2019 Jul; 38(7):817-819.
- A Review of Machine Learning Techniques for Keratoconus Detection and Refractive Surgery Screening. Semin Ophthalmol. 2019; 34(4):317-326.
- Spatially-resolved Brillouin spectroscopy reveals biomechanical abnormalities in mild to advanced keratoconus in vivo. Sci Rep. 2019 05 16; 9(1):7467.
- Developments in Imaging of Corneal Biomechanics. Int Ophthalmol Clin. 2019; 59(4):1-17.
- Predicting Refractive Outcome of Small Incision Lenticule Extraction for Myopia Using Corneal Properties. Transl Vis Sci Technol. 2018 Sep; 7(5):11.
- Lens regeneration in children. Nature. 2018 04 04; 556(7699):E2-E3.
- Descemetorhexis Without Endothelial Keratoplasty (DWEK): Proposal for Nomenclature Standardization. Cornea. 2018 04; 37(4):e20-e21.
- Predictive Factors for Corneal Clearance After Descemetorhexis Without Endothelial Keratoplasty. Cornea. 2018 Feb; 37(2):137-140.
- Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities. Cornea. 2018 Feb; 37(2):248-251.
- Phacoemulsification with intraocular lens implantation after previous descemetorhexis without endothelial keratoplasty. J Cataract Refract Surg. 2017 11; 43(11):1471-1475.
- Cataract surgery after proton-beam irradiation for uveal tumors. J Cataract Refract Surg. 2017 10; 43(10):1328-1334.
- Complications of Scleral-Fixated Intraocular Lenses. Semin Ophthalmol. 2018; 33(1):23-28.
- Cataract surgery outcomes and complications in retinal dystrophy patients. Can J Ophthalmol. 2017 Dec; 52(6):543-547.
- Anterior segment optical coherence tomography to look for Kayser-Fleischer rings. Pract Neurol. 2017 Jun; 17(3):222-223.
- The Quest for Spectacle Independence: A Comparison of Multifocal Intraocular Lens Implants and Pseudophakic Monovision for Patients with Presbyopia. Semin Ophthalmol. 2017; 32(1):111-115.
- Cataract in the Adult Eye Preferred Practice Pattern®. Ophthalmology. 2017 02; 124(2):P1-P119.
- In Vivo Brillouin Analysis of the Aging Crystalline Lens. Invest Ophthalmol Vis Sci. 2016 Oct 01; 57(13):5093-5100.
- Phakic Intraocular Lenses and their Special Indications. J Ophthalmic Vis Res. 2016 Oct-Dec; 11(4):422-428.
- Intravitreal Ozurdex® Implantation after Boston Type I Keratoprosthesis. Ocul Immunol Inflamm. 2018; 26(3):449-451.
- Persistent Blurry Vision After a Routine Eye Examination. JAMA Ophthalmol. 2016 09 01; 134(9):1065-6.
- Intraocular lens exchange surgery at a tertiary referral center: Indications, complications, and visual outcomes. J Cataract Refract Surg. 2016 09; 42(9):1262-1267.
- 3-Dimensional Patient-Derived Lung Cancer Assays Reveal Resistance to Standards-of-Care Promoted by Stromal Cells but Sensitivity to Histone Deacetylase Inhibitors. Mol Cancer Ther. 2016 04; 15(4):753-63.
- Corneal Transplantation in the Developing World: Lessons Learned and Meeting the Challenge. Cornea. 2015 Oct; 34 Suppl 10:S35-40.
- The evolution of corneal and refractive surgery with the femtosecond laser. Eye Vis (Lond). 2015; 2:12.
- Limitations of Keratoplasty in China: A Survey Analysis. PLoS One. 2015; 10(7):e0132268.
- Femtosecond laser-assisted keratopigmentation for the management of visual disabilities due to peripheral iridectomies. J Glaucoma. 2015 Apr-May; 24(4):e22-4.
- In vivo biomechanical mapping of normal and keratoconus corneas. JAMA Ophthalmol. 2015 Apr; 133(4):480-2.
- Dry eye after laser in-situ keratomileusis. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):358-62.
- Cataract and keratoconus: minimizing complications in intraocular lens calculations. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):376-9.
- Biomechanical characterization of keratoconus corneas ex vivo with Brillouin microscopy. Invest Ophthalmol Vis Sci. 2014 Jun 17; 55(7):4490-5.
- Infectious endophthalmitis in Boston keratoprosthesis: incidence and prevention. Acta Ophthalmol. 2014 Nov; 92(7):e546-55.
- Low-cost and readily available tissue carriers for the Boston keratoprosthesis: a review of possibilities. J Ophthalmol. 2013; 2013:686587.
- Indications for and outcomes of deep anterior lamellar keratoplasty in mucopolysaccharidoses. J Pediatr Ophthalmol Strabismus. 2013 Nov-Dec; 50(6):376-81.
- A novel approach to the management of a progressive Descemet membrane tear in a patient with keratoglobus and acute hydrops. Cornea. 2013 Mar; 32(3):355-8.
- Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus. Invest Ophthalmol Vis Sci. 2013 Feb 19; 54(2):1418-25.
- Analysis of four aberrometers for evaluating lower and higher order aberrations. PLoS One. 2013; 8(1):e54990.
- Traumatic in-the-bag intraocular lens subluxation. Int Ophthalmol Clin. 2013; 53(4):11-21.
- Practical applications of anterior segment optical coherence tomography imaging following corneal surgery. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):125-32.
- Intraoperative wavefront aberrometry in cataract surgery. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):100-6.
- Fungal keratitis with the type 1 Boston keratoprosthesis: early Indian experience. Cornea. 2012 Jul; 31(7):841-3.
- Two cases of cosmetic iris implant explantation secondary to uveitis, glaucoma, and corneal decompensation. Arch Ophthalmol. 2012 Jun; 130(6):787-9.
- Trichosporon asahii keratitis in a patient with a type I Boston keratoprosthesis and contact lens. Eye Contact Lens. 2012 Mar; 38(2):130-2.
- Brillouin optical microscopy for corneal biomechanics. Invest Ophthalmol Vis Sci. 2012 Jan 20; 53(1):185-90.
- Alcaligenes xylosoxidans contact lens-related keratitis--a case report and literature review. Eye Contact Lens. 2011 Nov; 37(6):386-9.
- Titanium back plate for a PMMA keratoprosthesis: clinical outcomes. Graefes Arch Clin Exp Ophthalmol. 2011 Oct; 249(10):1515-8.
- Phototherapeutic keratectomy outcomes in superficial corneal opacities. Ophthalmol Eye Dis. 2011; 3:1-6.
- Alternative applications of the femtosecond laser in ophthalmology. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):256-64.
- Corneal cross linking for keratoconus. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):249-55.
- Economic evaluation of toric intraocular lens: a short- and long-term decision analytic model. Arch Ophthalmol. 2010 Jul; 128(7):834-40.
- Role for ipsilateral autologous corneas as a carrier for the Boston keratoprosthesis: the Africa experience. Arch Ophthalmol. 2010 Jun; 128(6):795-7.
- Descemet's stripping endothelial keratoplasty: an effective treatment for toxic anterior segment syndrome with histopathologic findings. Cornea. 2010 Jun; 29(6):694-7.
- Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome. PLoS One. 2010 May 20; 5(5):e10659.
- Global corneal blindness and the Boston keratoprosthesis type I. Am J Ophthalmol. 2010 Apr; 149(4):537-9.
- Non-syndromic supernumerary caruncles causing ocular irritation after cataract surgery: a critical review of caruncular dysgeneses. Am J Ophthalmol. 2010 Mar; 149(3):398-404.e1-2.
- Phakic intraocular lenses. Int Ophthalmol Clin. 2010; 50(1):119-28.
- Epicorneal polypoidal lipodermoid: lack of association of central corneal lesions with goldenhar syndrome verified with a review of the literature. Surv Ophthalmol. 2010 Jan-Feb; 55(1):78-84.
- Intraocular lens calculations after corneal refractive surgery. Int Ophthalmol Clin. 2010; 50(1):181-9.
- Accommodating intraocular lenses: theory and practice. Int Ophthalmol Clin. 2010; 50(1):107-17.
- Arcuate keratotomy: an option for astigmatism correction after laser in situ keratomileusis. Cornea. 2009 Dec; 28(10):1178-80.
- Descemet's stripping endothelial keratoplasty: is it an option for congenital hereditary endothelial dystrophy? Int Ophthalmol. 2010 Jun; 30(3):307-10.
- Reactivated herpetic keratitis following laser in situ keratomileusis. J Cataract Refract Surg. 2009 May; 35(5):946-8.
- Topical bevacizumab in the treatment of corneal neovascularization: results of a prospective, open-label, noncomparative study. Arch Ophthalmol. 2009 Apr; 127(4):381-9.
- Complications of cosmetic iris implants. J Cataract Refract Surg. 2008 Jul; 34(7):1222-4.
- Trends in resistance to ciprofloxacin, cefazolin, and gentamicin in the treatment of bacterial keratitis. J Ocul Pharmacol Ther. 2008 Apr; 24(2):217-23.
- Optic neuropathy after epi-LASIK. J Refract Surg. 2008 02; 24(2):204-8.
- Safety and efficacy of PRK and LASIK in pediatric patients. Int Ophthalmol Clin. 2008; 48(2):193-208.
- Post-LASIK epithelial dendritic defect associated with Alternaria. Cornea. 2007 Oct; 26(9):1144-6.
- Visual outcome and rehabilitation in a case of bilateral acanthamoeba sclerokeratitis. Cornea. 2007 Oct; 26(9):1150-2.
- Atypical mycobacteria keratitis after laser in situ keratomileusis unresponsive to fourth-generation fluoroquinolone therapy. J Cataract Refract Surg. 2007 Jul; 33(7):1318-21.
- Outcomes of Boston keratoprosthesis in aniridia: a retrospective multicenter study. Am J Ophthalmol. 2007 Aug; 144(2):227-231.
- LASIK-associated atypical mycobacteria keratitis: a case report and review of the literature. Int Ophthalmol Clin. 2007; 47(2):73-84.
- Myopic laser in situ keratomileusis in eyes with thick corneas. J Cataract Refract Surg. 2006 May; 32(5):900-1.
- Corneal ulceration and perforation with ketorolac tromethamine (Acular) use after PRK. Cornea. 2006 Feb; 25(2):232-4.
- Discoid lupus erythematosus masquerading as chronic blepharoconjunctivitis. Ophthalmology. 2005 May; 112(5):e19-23.
- Controversies in management of bacterial keratitis. Int Ophthalmol Clin. 2005; 45(4):199-210.
- Conductive keratoplasty. Int Ophthalmol Clin. 2004; 44(1):161-8.
- Laser cataract surgery: past, present, and evolving technologies. Int Ophthalmol Clin. 2004; 44(1):113-21.
- Antibiotic advances in ophthalmology. Int Ophthalmol Clin. 2004; 44(3):91-102.
- Phacoemulsification and thermal wound injury. Semin Ophthalmol. 2002 Sep-Dec; 17(3-4):102-9.
- Descemet membrane tear after cataract surgery. Semin Ophthalmol. 2002 Sep-Dec; 17(3-4):115-9.
- Epithelial and fibrous downgrowth: mechanisms of disease. Ophthalmol Clin North Am. 2002 Mar; 15(1):41-8.
- Management of astigmatism after corneal trauma. Int Ophthalmol Clin. 2002; 42(3):47-55.
- Traumatic ruptured globe injuries in children. Int Ophthalmol Clin. 2002; 42(3):157-65.
- Diffuse lamellar keratitis: incidence, associations, outcomes, and a new classification system. J Cataract Refract Surg. 2001 Oct; 27(10):1560-6.
- Postoperative complications of periocular anesthesia. Int Ophthalmol Clin. 2000; 40(1):85-91.
- Hypertrophic discoid lupus erythematosus of the conjunctiva. Am J Ophthalmol. 1999 May; 127(5):604-5.
- Late onset of haze associated with viral keratoconjunctivitis following photorefractive keratectomy. J Refract Surg. 1998 Mar-Apr; 14(2):147-51.
- Establishment of a rabbit model of extrascleral extension of ocular melanoma. Retina. 1998; 18(4):368-72.
- A study of topical nonsteroidal anti-inflammatory drops and no pressure patching in the treatment of corneal abrasions. Corneal Abrasion Patching Study Group. Ophthalmology. 1997 Aug; 104(8):1353-9.
- Magnetic resonance imaging of cyclodialysis clefts. Graefes Arch Clin Exp Ophthalmol. 1997 Jul; 235(7):468-71.
- Adjunctive therapy and surgical considerations in the management of bacterial ulcerative keratitis. Int Ophthalmol Clin. 1996; 36(3):37-48.
- Cutaneous melanoma-associated retinopathy with retinal periphlebitis. Arch Ophthalmol. 1995 Jul; 113(7):854-5.
- Ciliary body neurilemoma. Unusual clinical findings intimating the diagnosis. Ophthalmology. 1995 Jun; 102(6):918-23.
- The role of steroids in the management of Acanthamoeba keratitis, fungal keratitis, and epidemic keratoconjunctivitis. Int Ophthalmol Clin. 1994; 34(3):19-31.
- Human retinoblastoma cells express alpha B-crystallin in vivo and in vitro. Curr Eye Res. 1993 Mar; 12(3):239-45.
- 'Black cornea' after long-term epinephrine use. Arch Ophthalmol. 1992 Sep; 110(9):1273-5.
- Ocular changes in the mucopolysaccharidoses after bone marrow transplantation. A preliminary report. Ophthalmology. 1989 Jul; 96(7):977-84; discussion 984-5.
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