Basil S. Pawlyk, M.Sc.

Research Summary

Center/Research Area Affiliations

Research Summary

Basil’s interests are related to the characterization of genetically developed, as well as naturally occurring, animal models of retinal degeneration using histological, histochemical and electrophysiological assays. These have included animal models for leber congenital amaurosis (LCA), genetic forms of retinitis pigmentosa (dominant, recessive, and X-linked RP), and usher syndrome (USH 2A). More recently, he has helped to develop and evaluate various forms of potential therapies for retinal degeneration in mouse models which have included nutritional supplements (Vitamin A) as well as replacement gene therapy. Mouse models of LCA (AIPL1, TULP1, and RPGRIP1) and X-linked RP (RPGR) have responded to replacement gene therapy.