George N. Papaliodis,
MD
Massachusetts Eye and Ear
Associate Scientist
Harvard Medical School
Associate Professor of Ophthalmology
About My Research
Dr. Papaliodis' research has focused on attempting to identify disease mechanisms that can induce uveitis and novel treatments for intraocular inflammation. He has studied serum biomarkers and genetics in ocular sarcoidosis along with the role of vitamin D in ocular inflammatory disorders. He has been an investigator in multiple drug-company sponsored clinical trials to establish the efficacy of therapeutic agents for uveitis. In collaboration with Dr. John Kempen, he is currently assessing factors that may influence the development of ocular complications in those who have intraocular inflammation.
Education
1992: BS, Chemistry, Physics, and Biology, summa cum laude, Texas Christian University
1995: MD, University of Texas Southwestern Medical School
Postgraduate Training
1996: Internship, Internal Medicine, Massachusetts General Hospital
1999: Residency, Ophthalmology, University of Texas Southwestern
2001: Residency, Internal Medicine, Massachusetts General Hospital
2002: Fellowship, Ocular Immunology and Uveitis, Massachusetts Eye and Ear
Academic Appointments
2018-present: Associate Professor of Ophthalmology, Harvard Medical School
2011-2018: Assistant Professor of Ophthalmology, Harvard Medical School
2005-2011: Instructor in Ophthalmology, Harvard Medical School
2003-2005: Instructor in Medicine, Harvard Medical School
2002-2003: Instructor in Ophthalmology, Harvard Medical School
Professional Memberships
American Uveitis Society
Honors
Massachusetts Eye and Ear Resident Teaching Award
Publications powered by Harvard Catalyst Profiles
- Concurrence of Ocular Cicatricial Pemphigoid in Chronic Ocular Graft-Versus-Host Disease. Cornea. 2024 Mar 01; 43(3):387-390.
- The prophylactic value of TNF-a inhibitors against retinal cell apoptosis and optic nerve axon loss after corneal surgery or trauma. Acta Ophthalmol. 2024 May; 102(3):e381-e394.
- Incidence of and Risk Factors for Cataract in Anterior Uveitis. Am J Ophthalmol. 2023 10; 254:221-232.
- Tubulointerstitial nephritis and uveitis syndrome (TINU) following COVID-19 vaccination. Am J Ophthalmol Case Rep. 2023 Sep; 31:101869.
- High Positive Predictive Value of Fluorescein Angiography Contiguous, Perineural Retinal Vascular Leakage Pattern for Birdshot Chorioretinopathy. Ocul Immunol Inflamm. 2024 Jan; 32(1):48-53.
- Mendelian Randomization Shows a Causal Effect of Low Vitamin D on Non-infectious Uveitis and Scleritis Risk. Am J Ophthalmol. 2022 Dec; 244:11-18.
- Restoration of Vision in Severe, Cicatricial, Ocular Surface Disease With the Boston Keratoprosthesis Type II. Am J Ophthalmol. 2022 11; 243:42-54.
- Anti-infliximab antibodies and clinical response in noninfectious uveitis and scleritis patients treated with infliximab: A retrospective review. Am J Ophthalmol Case Rep. 2022 Sep; 27:101634.
- Primary central nervous system lymphoma: Inter-compartmental progression. EJHaem. 2022 May; 3(2):362-370.
- Uveitis Specialists Harnessing Disruptive Technology during the COVID-19 Pandemic and Beyond. Semin Ophthalmol. 2021 May 19; 36(4):296-303.
- Comparison of Modified Posterior Sub-Tenon's vs. Trans-Septal Triamcinolone Injection for Non-infectious Uveitis. Ocul Immunol Inflamm. 2021 Jul 04; 29(5):857-864.
- Real-Time Multiplex PCR Analysis in Infectious Uveitis. Semin Ophthalmol. 2019; 34(4):252-255.
- Ocular Adverse Events following Use of Immune Checkpoint Inhibitors for Metastatic Malignancies. Ocul Immunol Inflamm. 2020 Aug 17; 28(6):854-859.
- Association of Low Vitamin D Levels with Noninfectious Uveitis and Scleritis. Ocul Immunol Inflamm. 2019; 27(4):602-609.
- A 70-Year-Old Man With Pain and a Creamy Elevated Lesion After Transscleral Cyclophotocoagulation. JAMA Ophthalmol. 2018 02 01; 136(2):209-210.
- Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities. Cornea. 2018 Feb; 37(2):248-251.
- Association of genetic variants in RAB23 and ANXA11 with uveitis in sarcoidosis. Mol Vis. 2018; 24:59-74.
- Cataract Surgery Complications in Uveitis Patients: A Review Article. Semin Ophthalmol. 2018; 33(1):64-69.
- Ophthalmologic manifestations of systemic vasculitis. Curr Opin Ophthalmol. 2017 Nov; 28(6):613-616.
- A retrospective study on the outcomes of Ahmed valve versus Ahmed valve combined with fluocinolone implant in uveitic glaucoma. Digit J Ophthalmol. 2017; 23(3):63-70.
- Pre-papillary vitreous opacities associated with Behçet's disease: a case series and review of the literature. Graefes Arch Clin Exp Ophthalmol. 2017 Oct; 255(10):2017-2021.
- Association of Low Vitamin D Levels With Noninfectious Anterior Uveitis. JAMA Ophthalmol. 2017 02 01; 135(2):150-153.
- A Review of the Course and Treatment of Non-Infectious Uveitis during Pregnancy. Semin Ophthalmol. 2017; 32(1):75-81.
- CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 20-2016. A 50-Year-Old Man with Cloudy Vision, Hearing Loss, and Unsteadiness. N Engl J Med. 2016 Jun 30; 374(26):2586-93.
- NOD2 genetic variants and sarcoidosis-associated uveitis. Am J Ophthalmol Case Rep. 2016 Oct; 3:39-42.
- Infliximab after Boston Keratoprosthesis in Stevens-Johnson Syndrome: An Update. Ocul Immunol Inflamm. 2017 Jun; 25(3):413-417.
- Unilateral Eye Findings: A Rare Herald of Acute Leukemia. Ocul Oncol Pathol. 2016 Apr; 2(3):166-70.
- Chronic Ocular Complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: The Role of Systemic Immunomodulatory Therapy. Semin Ophthalmol. 2016; 31(1-2):178-87.
- The role of serological titres in the diagnosis of ocular toxoplasmosis. Acta Ophthalmol. 2016 Aug; 94(5):521-2.
- Accuracy of the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) as a research tool for identification of patients with uveitis and scleritis. Ophthalmic Epidemiol. 2015 Apr; 22(2):139-41.
- Cogan syndrome with severe medium and large vessel vasculitis. Digit J Ophthalmol. 2016; 22(1):32-4.
- Ocular ischemic syndrome presenting as retinal vasculitis in a patient with moyamoya syndrome. Retin Cases Brief Rep. 2015; 9(2):170-2.
- Side-effects of anti-inflammatory therapy in uveitis. Semin Ophthalmol. 2014 Sep-Nov; 29(5-6):456-67.
- Ocular inflammatory disease in patients with polymyalgia rheumatica: A case series and review of the literature. Clin Rheumatol. 2016 Jan; 35(1):251-8.
- Treatment of seronegative spondyloarthropathy-associated uveitis with golimumab: retrospective case series. Clin Exp Ophthalmol. 2014 May-Jun; 42(4):392-5.
- Role of OCT in the diagnosis and management of macular edema from uveitis. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):236-41.
- Golimumab for the treatment of refractory juvenile idiopathic arthritis-associated uveitis. J Ophthalmic Inflamm Infect. 2012 Dec; 2(4):231-3.
- Case records of the Massachusetts General Hospital. Case 24-2011. A 36-year-old man with headache, memory loss, and confusion. N Engl J Med. 2011 Aug 11; 365(6):549-59.
- The use of biologic agents in the treatment of ocular manifestations of Behcet's disease. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):295-303.
- Cost effectiveness of the type II Boston keratoprosthesis. Eye (Lond). 2011 Mar; 25(3):342-9.
- Drug delivery options for the treatment of ocular inflammation. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):283-8.
- Ocular syphilis among HIV-infected patients: a systematic analysis of the literature. Sex Transm Infect. 2011 Feb; 87(1):4-8.
- Ocular syphilis among HIV-infected individuals. Clin Infect Dis. 2010 Aug 15; 51(4):468-71.
- Keratoprosthesis in autoimmune disease. Ocul Immunol Inflamm. 2010 Aug; 18(4):275-80.
- Wegener's granulomatosis: clinical manifestations, differential diagnosis, and management of ocular and systemic disease. Surv Ophthalmol. 2010 Sep-Oct; 55(5):429-44.
- Case records of the Massachusetts General Hospital. Case 4-2010. A 53-year-old man with arthralgias, oral ulcers, vision loss, and vocal-cord paralysis. N Engl J Med. 2010 Feb 11; 362(6):537-46.
- A 37-year-old man with a black spot in his vision. Digit J Ophthalmol. 2010; 16(1):1-5.
- A 29-year-old woman with headache, fever, right leg numbness, and dysphagia. Arthritis Care Res (Hoboken). 2010 Feb; 62(2):283-90.
- Paraneoplastic conjunctival cicatrization: two different pathogenic types. Ophthalmology. 2010 Apr; 117(4):659-64.
- Perioperative evaluation and management of cataract surgery in uveitis patients. Int Ophthalmol Clin. 2010; 50(1):129-37.
- Selection of intraocular lenses in patients with uveitis. Int Ophthalmol Clin. 2010; 50(1):61-70.
- Primary T-cell lymphoma of the retina and cerebellum: immunophenotypic and gene rearrangement confirmation. Am J Ophthalmol. 2009 Sep; 148(3):350-60.
- An evidence-based systematic review of bilberry (Vaccinium myrtillus) by the Natural Standard Research Collaboration. J Diet Suppl. 2009; 6(2):162-200.
- Enterobacter amnigenus endophthalmitis. Retin Cases Brief Rep. 2009; 3(4):409-11.
- Pseudo-hypopyon as the presenting feature of recurrent B-cell lymphoma. Ocul Immunol Inflamm. 2008 May-Jun; 16(3):121-2.
- Posterior synechiae secondary to uveitis. J Pediatr Ophthalmol Strabismus. 2008 Jan-Feb; 45(1):64.
- Genetics of birdshot chorioretinopathy. Semin Ophthalmol. 2008 Jan-Feb; 23(1):53-7.
- The genetics of Adamantiades-Behcet's disease. Semin Ophthalmol. 2008 Jan-Feb; 23(1):73-9.
- Chapter 168: Frosted Branch Angiitis. Principles and Practice of Ophthalmology. 2008.
- Relative risk for cancer in mucous membrane pemphigoid associated with antibodies to the beta4 integrin subunit. Clin Exp Dermatol. 2007 Nov; 32(6):637-41.
- Plasmapheresis for lupus retinal vasculitis. Arch Ophthalmol. 2006 Nov; 124(11):1654-6.
- Cyclosporine and mycophenolate mofetil: The Massachusetts Eye and Ear Infirmary Experience in the treatment of Birdshot Retinochoroidopathy. Middle East Journal of Ophthalmology. 2006; 13(4):129-135.
- Ocular Anti-Inflammatory Agents. PDR for Ophthalmic Medicines. 2006.
- Stevens-Johnson syndrome and toxic epidermal necrolysis: a review of the literature. Ann Allergy Asthma Immunol. 2005 Apr; 94(4):419-36; quiz 436-8, 456.
- Elevated levels of interleukin 6 in the vitreous fluid of patients with pars planitis and posterior uveitis: the Massachusetts eye & ear experience and review of previous studies. Ocul Immunol Inflamm. 2004 Sep; 12(3):193-201.
- Pulse IV cyclophosphamide in ocular inflammatory disease: efficacy and short-term safety. Ophthalmology. 2004 May; 111(5):960-5.
- Treatment of ocular inflammatory disorders with daclizumab. Ophthalmology. 2003 Apr; 110(4):786-9.
- Intraocular lens tolerance in surgery for cataracta complicata: assessment of four implant materials. Semin Ophthalmol. 2002 Sep-Dec; 17(3-4):120-3.
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