Hideko Heidi Nakajima,
MD, PhD
Massachusetts Eye and Ear
Investigator, Eaton-Peabody Laboratories
Harvard Medical School
Gudrun Larsen Eliasen and Nels Kristian Eliasen Associate Professor of Otolaryngology–Head and Neck Surgery
Phone:
617-573-6954
About My Research
Dr. Heidi Nakajima’s primary research interests include human auditory mechanics, middle ear prostheses, acoustical stimulation of the cochlea, and the development of diagnostics and treatments for middle and inner ear disease. Her research addresses fundamental scientific questions about the auditory system and develops new and improved methods to diagnose and treat human hearing disease. She accomplishes this through experiments on human cadaveric preparations, clinical measurements on live humans, and computational modeling of the hearing system.
Publications powered by Harvard Catalyst Profiles
- Correction: An Implantable Piezofilm Middle Ear Microphone: Performance in Human Cadaveric Temporal Bones. J Assoc Res Otolaryngol. 2024 Feb; 25(1):89.
- An Implantable Piezofilm Middle Ear Microphone: Performance in Human Cadaveric Temporal Bones. J Assoc Res Otolaryngol. 2024 Feb; 25(1):53-61.
- The UmboMic: A PVDF Cantilever Microphone. ArXiv. 2023 Dec 22.
- Sheep as a Large-Animal Model for Otology Research: Temporal Bone Extraction and Transmastoid Facial Recess Surgical Approach. J Assoc Res Otolaryngol. 2023 Oct; 24(5):487-497.
- Round window stimulation with an interface coupler demonstrates proof of concept. Hear Res. 2022 08; 421:108512.
- Consensus Statement on Bone Conduction Devices and Active Middle Ear Implants in Conductive and Mixed Hearing Loss. Otol Neurotol. 2022 06 01; 43(5):513-529.
- Preserving Wideband Tympanometry Information With Artifact Mitigation. Ear Hear. 2022 Mar/Apr; 43(2):563-576.
- An Implantable Umbo Microphone For Fully-Implantable Assistive Hearing Devices. IEEE Sens J. 2021; 2021.
- Mechanics of Total Drum Replacement Tympanoplasty Studied With Wideband Acoustic Immittance. Otolaryngol Head Neck Surg. 2022 04; 166(4):738-745.
- Current Trends, Controversies, and Future Directions in the Evaluation and Management of Superior Canal Dehiscence Syndrome. Front Neurol. 2021; 12:638574.
- Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism. Sci Rep. 2020 10 06; 10(1):16564.
- Superior Canal Dehiscence Similarly Affects Cochlear Pressures in Temporal Bones and Audiograms in Patients. Ear Hear. 2020 Jul/Aug; 41(4):804-810.
- Anatomy of the Human Osseous Spiral Lamina and Cochlear Partition Bridge: Relevance for Cochlear Partition Motion. J Assoc Res Otolaryngol. 2020 04; 21(2):171-182.
- Effect of Middle-Ear Pathology on High-Frequency Ear Canal Reflectance Measurements in the Frequency and Time Domains. J Assoc Res Otolaryngol. 2019 12; 20(6):529-552.
- Cochlear partition anatomy and motion in humans differ from the classic view of mammals. Proc Natl Acad Sci U S A. 2019 07 09; 116(28):13977-13982.
- Superior Canal Dehiscence Surgery Outcomes Following Failed Round Window Surgery. Otol Neurotol. 2019 04; 40(4):535-542.
- A Vibro-Acoustic Hybrid Implantable Microphone for Middle Ear Hearing Aids and Cochlear Implants. Sensors (Basel). 2019 Mar 05; 19(5).
- Fracture of the Incus Caused by Digital Manipulation of the Ear Canal and its Diagnosis Using Wideband Acoustic Immittance. Otol Neurotol. 2019 02; 40(2):e115-e118.
- Utility of Postoperative Magnetic Resonance Imaging in Patients Who Fail Superior Canal Dehiscence Surgery. Otol Neurotol. 2019 01; 40(1):130-138.
- Intracochlear Sound Pressure Measurements in Normal Human Temporal Bones During Bone Conduction Stimulation. J Assoc Res Otolaryngol. 2018 10; 19(5):523-539.
- Infrasound transmission in the human ear: Implications for acoustic and vestibular responses of the normal and dehiscent inner ear. J Acoust Soc Am. 2018 07; 144(1):332.
- Impedances of the inner and middle ear estimated from intracochlear sound pressures in normal human temporal bones. Hear Res. 2018 09; 367:17-31.
- PVDF-Based Piezoelectric Microphone for Sound Detection Inside the Cochlea: Toward Totally Implantable Cochlear Implants. Trends Hear. 2018 Jan-Dec; 22:2331216518774450.
- Limits on normal cochlear 'third' windows provided by previous investigations of additional sound paths into and out of the cat inner ear. Hear Res. 2018 03; 360:3-13.
- An Intracochlear Pressure Sensor as a Microphone for a Fully Implantable Cochlear Implant. Otol Neurotol. 2016 12; 37(10):1596-1600.
- Tectorial Membrane Traveling Waves Underlie Sharp Auditory Tuning in Humans. Biophys J. 2016 Sep 06; 111(5):921-4.
- Controlled exploration of the effects of conductive hearing loss on wideband acoustic immittance in human cadaveric preparations. Hear Res. 2016 11; 341:19-30.
- The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity. Ear Hear. 2016 Mar-Apr; 37(2):206-15.
- Characteristics of Wax Occlusion in the Surgical Repair of Superior Canal Dehiscence in Human Temporal Bone Specimens. Otol Neurotol. 2016 Jan; 37(1):83-8.
- Delayed loss of hearing after hearing preservation cochlear implantation: Human temporal bone pathology and implications for etiology. Hear Res. 2016 Mar; 333:225-234.
- Three-Dimensional Printed Prosthesis for Repair of Superior Canal Dehiscence. Otolaryngol Head Neck Surg. 2015 Oct; 153(4):616-9.
- Prolonged Radiant Exposure of the Middle Ear during Transcanal Endoscopic Ear Surgery. Otolaryngol Head Neck Surg. 2015 Jul; 153(1):102-4.
- Power reflectance as a screening tool for the diagnosis of superior semicircular canal dehiscence. Otol Neurotol. 2015 Jan; 36(1):172-7.
- A Fully-Implantable Cochlear Implant SoC with Piezoelectric Middle-Ear Sensor and Arbitrary Waveform Neural Stimulation. IEEE J Solid-State Circuits. 2015 Jan 01; 50(1):214-229.
- Assessment of the effects of superior canal dehiscence location and size on intracochlear sound pressures. Audiol Neurootol. 2015; 20(1):62-71.
- Thermal effects of endoscopy in a human temporal bone model: implications for endoscopic ear surgery. Laryngoscope. 2014 Aug; 124(8):E332-9.
- Non-invasive methods for diagnosing diseases of the ear: Wideband acoustic immittance and umbo velocity. J Acoust Soc Am. 2014 Apr; 135(4):2277.
- Superior canal dehiscence length and location influences clinical presentation and audiometric and cervical vestibular-evoked myogenic potential testing. Audiol Neurootol. 2014; 19(2):97-105.
- Assessment of ear disorders using power reflectance. Ear Hear. 2013 Jul; 34 Suppl 1:48S-53S.
- Consensus statement: Eriksholm workshop on wideband absorbance measures of the middle ear. Ear Hear. 2013 Jul; 34 Suppl 1:78S-79S.
- Wideband acoustic immittance: tympanometric measures. Ear Hear. 2013 Jul; 34 Suppl 1:65S-71S.
- Comparison of forward (ear-canal) and reverse (round-window) sound stimulation of the cochlea. Hear Res. 2013 Jul; 301:105-14.
- The effect of superior semicircular canal dehiscence on intracochlear sound pressures. Audiol Neurootol. 2012; 17(5):338-48.
- Comparison of ear-canal reflectance and umbo velocity in patients with conductive hearing loss: a preliminary study. Ear Hear. 2012 Jan-Feb; 33(1):35-43.
- Ear-canal reflectance, umbo velocity, and tympanometry in normal-hearing adults. Ear Hear. 2012 Jan-Feb; 33(1):19-34.
- Evaluation of round window stimulation using the floating mass transducer by intracochlear sound pressure measurements in human temporal bones. Otol Neurotol. 2010 Apr; 31(3):506-11.
- Performance considerations of prosthetic actuators for round-window stimulation. Hear Res. 2010 May; 263(1-2):114-9.
- Head rotation evoked tinnitus due to superior semicircular canal dehiscence. J Laryngol Otol. 2010 Mar; 124(3):333-5.
- Differential intracochlear sound pressure measurements in normal human temporal bones. J Assoc Res Otolaryngol. 2009 Mar; 10(1):23-36.
- Clinical utility of laser-Doppler vibrometer measurements in live normal and pathologic human ears. Ear Hear. 2008 Jan; 29(1):3-19.
- Clinical investigation and mechanism of air-bone gaps in large vestibular aqueduct syndrome. Ann Otol Rhinol Laryngol. 2007 Jul; 116(7):532-41.
- Experimental ossicular fixations and the middle ear's response to sound: evidence for a flexible ossicular chain. Hear Res. 2005 Jun; 204(1-2):60-77.
- Experimental and clinical studies of malleus fixation. Laryngoscope. 2005 Jan; 115(1):147-54.
- Clinical, experimental, and theoretical investigations of the effect of superior semicircular canal dehiscence on hearing mechanisms. Otol Neurotol. 2004 May; 25(3):323-32.
- Effects of acoustic trauma on acoustic enhancement of electrically evoked otoacoustic emissions. J Acoust Soc Am. 2000 May; 107(5 Pt 1):2603-14.
- Nonlinear characteristics of electrically evoked otoacoustic emissions. Hear Res. 1998 Aug; 122(1-2):109-18.
- Acoustic overstimulation enhances low-frequency electrically-evoked otoacoustic emissions and reduces high-frequency emissions. Auditory Neuroscience. 1996; 3:79-99.
- Electrically evoked otoacoustic emissions from the apical turns of the gerbil cochlea. J Acoust Soc Am. 1994 Aug; 96(2 Pt 1):786-94.
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