Milica Margeta, M.D., Ph.D.

Research Summary

Research Summary

Dr. Margeta is a glaucoma specialist, which is a chronic blinding disease characterized by gradual loss of retinal ganglion cells and cupping of the optic nerve. Elevated intraocular pressure remains the only modifiable risk factor for glaucoma; currently there no treatments conferring retinal ganglion cell neuroprotection or reversing existing visual field loss. As a K12 scholar, Dr. Margeta is investigating the role of the innate immune system, bone marrow-derived macrophages and resident microglia, in pathogenesis of glaucoma, with the goal of developing novel neuroprotective treatments for this progressive blinding disease.

Selected Publications

For a full publications list, please see her CV.

Low cerebrospinal fluid protein in prepubertal children with idiopathic intracranial hypertension. Margeta MA, Buckley EG, El-Dairi M. J AAPOS. 2015;19:135-9.

Molecular mechanisms of synaptic specificity. Margeta MA, Shen K. Mol Cell Neurosci. 2010;43:261-7

Clathrin adaptor AP-1 complex excludes multiple postsynaptic receptors from axons in C. elegans. Margeta MA, Wang GJ, Shen K. Proc Natl Acad Sci USA. 2009;106:1632-7

Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans.  Margeta, MA, Shen, K, Grill B. Curr Opin Neurobiol. 2008;18:69-76

Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Colón-Ramos DA, Margeta MA, Shen K. Science. 2007; 318: 103-6.

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2003: BS, Stanford University, Biological Sciences

2009: PhD, Stanford University, Neuroscience

2011: MD, Stanford University

Postgraduate Training

Duke University, Ophthalmology Resident (2012-2015)

Duke University, Glaucoma Fellow (2015-2016)


2013 – Robert Machemer Resident Research Award, Duke University Eye Center

2015 – Ocular Innovation Award, Duke University Eye Center