Daniel R. Lefebvre,
MD
Massachusetts Eye and Ear
Assistant Scientist
Harvard Medical School
Assistant Professor of Ophthalmology
daniel_lefebvre@meei.harvard.edu
For investigator inquiries only
About My Research
Dr. Lefebvre specializes in evaluating and treating disorders of the eyelids, lacrimal system, and orbit, with special interest in trauma, thyroid eye disease, eyelid and orbital anatomy, and eyelid and orbital oncology. Currently, he is conducting a CT-based analysis of orbital anatomy; a study on the effect of camera/flash type and reflex position in standardized facial photography; a review of eyelid/canalicular trauma series; as well as an investigation into the anatomy and physiology of Muellers muscle of the eyelid.
Education
2000: BS, Biology, Boston University
2005: MD, SUNY Upstate Medical University
Postgraduate Training
2006: Internship, General Surgery, Thomas Jefferson University Hospital
2010: Residency, Ophthalmology, Nassau University Medical Center
2011: Fellowship, Ophthalmic Plastic and Reconstructive Surgery, Boston University
2012: Fellowship, Ophthalmic Plastic and Reconstructive Surgery, Massachusetts Eye and Ear
Academic Appointments
2015-present: Assistant Professor of Ophthalmology, Harvard Medical School
2012-2015: Instructor in Ophthalmology, Harvard Medical School
2010-2011: Instructor in Ophthalmology, Boston University School of Medicine
Publications powered by Harvard Catalyst Profiles
- Orbital Penetrating Injuries: A Review on Evaluation and Management. Int Ophthalmol Clin. 2024 Apr 01; 64(2):11-29.
- Periorbital necrotizing sweet syndrome: A report of two cases mimicking necrotizing soft tissue infections. Am J Ophthalmol Case Rep. 2024 Jun; 34:102033.
- A Rapidly Expanding Hemorrhagic BRAF-Mutant Orbital Atypical Glomus Tumor. Ophthalmic Plast Reconstr Surg. 2024 Jan-Feb 01; 40(1):e11-e14.
- Antibiotic utilization in endoscopic dacryocystorhinostomy: a multi-institutional study and review of the literature. Orbit. 2024 Apr; 43(2):183-189.
- Perceived change in age after functional upper blepharoplasty. Orbit. 2024 Apr; 43(2):165-167.
- Silicone Granulomas of the Eyelids-A Case Series Illustrating a Distant Migratory Phenomenon. Ophthalmic Plast Reconstr Surg. 2023 Jan-Feb 01; 39(1):81-87.
- Optic Perineuritis Associated With Cryptococcal Meningitis Presenting With a Hot Orbit in a Patient With Chronic Lymphocytic Leukemia. J Neuroophthalmol. 2022 06 01; 42(2):272-277.
- ARHGEF-10 gene mutation presenting as orbital inflammatory syndrome. BMJ Case Rep. 2022 Mar 08; 15(3).
- Medical comorbidities and orbital implant exposure. Acta Ophthalmol. 2022 May; 100(3):e813-e819.
- Orbital Involvement by Biphenotypic Sinonasal Sarcoma With a Literature Review. Ophthalmic Plast Reconstr Surg. 2021 Jul-Aug 01; 37(4):305-311.
- In vivo analysis of endocanalicular light pipe transillumination in endoscopic dacryocystorhinostomy: Anatomic considerations and cautions for the transitioning. Orbit. 2022 Aug; 41(4):447-451.
- Adult-onset asthma and periocular xanthogranuloma - A rare infiltrative disease of the orbit and eyelid. Am J Ophthalmol Case Rep. 2021 Jun; 22:101043.
- Lower eyelid malposition following repair of complex orbitofacial trauma. Orbit. 2022 Apr; 41(2):193-198.
- Sclerosing Signet Ring Cell Carcinoma of the Lacrimal Gland: A Potentially New Primary Entity. Ocul Oncol Pathol. 2020 Aug; 6(4):265-274.
- Poor prognoses of open globe injuries with concomitant orbital fractures. Orbit. 2020 Aug; 39(4):241-250.
- Intraductal sebaceous papilloma of a meibomian gland: a new entity possibly associated with the MSH6 subtype of the Muir-Torre syndrome. Surv Ophthalmol. 2020 Mar - Apr; 65(2):227-238.
- Assessment of Infraorbital Hypesthesia Following Orbital Floor and Zygomaticomaxillary Complex Fractures Using a Novel Sensory Grading System. Ophthalmic Plast Reconstr Surg. 2019 Jan/Feb; 35(1):53-55.
- Ophthalmic Plastic Surgery in Patients 100 Years and Older. Ophthalmic Plast Reconstr Surg. 2019 Jan/Feb; 35(1):71-76.
- Case 39-2018: An 18-Year-Old Man with Diplopia and Proptosis of the Left Eye. N Engl J Med. 2018 12 20; 379(25):2452-2461.
- Mild Complications or Unusual Persistence of Porcine Collagen and Hyaluronic Acid Gel Following Periocular Filler Injections. Ophthalmic Plast Reconstr Surg. 2018 Sep/Oct; 34(5):e143-e146.
- Osseous cavernous hemangioma of the superior orbital rim. Orbit. 2019 Jun; 38(3):259.
- Revision eDCR using a superior pedicled mucosal flap. Orbit. 2019 Feb; 38(1):1-6.
- Human Bot Fly Infestation of the Eyelid. Ophthalmic Plast Reconstr Surg. 2018 Jan/Feb; 34(1):e36.
- Orbital leiomyosarcoma metastasis presenting prior to diagnosis of the primary tumor. Digit J Ophthalmol. 2017; 23(4):22-26.
- Long-term impact of endoscopic orbital decompression on sinonasal-specific quality of life. Laryngoscope. 2018 04; 128(4):785-788.
- A Retrospective Review of Orbital Decompression for Thyroid Orbitopathy with Endoscopic Preservation of the Inferomedial Orbital Bone Strut. Ophthalmic Plast Reconstr Surg. 2017 Sep/Oct; 33(5):334-339.
- Endoscopic DCR using bipedicled interlacing mucosal flaps. Laryngoscope. 2018 04; 128(4):794-797.
- Uniformly Sclerotic Diffuse Large B-Cell Lymphoma of the Orbit. Ophthalmic Plast Reconstr Surg. 2017 May/Jun; 33(3S Suppl 1):S127-S129.
- A 64-year-old man with an unusual conjunctival cyst. Digit J Ophthalmol. 2017; 23(1):40-42.
- Pseudomonas Aeruginosa: A Masquerader in Sino-Orbital Infections. Ophthalmic Plast Reconstr Surg. 2016 Sep-Oct; 32(5):374-7.
- Impact of endoscopic dacryocystorhinostomy on sinonasal quality of life. Am J Rhinol Allergy. 2016 Sep; 30(5):189-91.
- Clinical and microbiologic features of dacryocystitis-related orbital cellulitis. Orbit. 2016 Oct; 35(5):258-61.
- Orbital exenteration: The 10-year Massachusetts Eye and Ear Infirmary experience. Orbit. 2016 Aug; 35(4):199-206.
- Chronic orbital and calvarial fungal infection with Apophysomyces variabilis in an immunocompetent patient. Surv Ophthalmol. 2017 Jan - Feb; 62(1):70-82.
- Margin Reflex Distance: Differences Based on Camera and Flash Positions. Ophthalmic Plast Reconstr Surg. 2016 May-Jun; 32(3):199-203.
- Comparative techniques of medial rectus muscle retraction for endoscopic exposure of the medial intraconal space. Am J Rhinol Allergy. 2016 May; 30(3):226-9.
- Validation of the facial assessment by computer evaluation (FACE) program for software-aided eyelid measurements. Orbit. 2016 Jun; 35(3):117-20.
- Current trends in the management of thyroid eye disease. Curr Opin Ophthalmol. 2015 Nov; 26(6):484-90.
- External dacryocystorhinostomy outcomes in patients with a history of dacryocystitis. Digit J Ophthalmol. 2015; 21(3):1-22.
- Spontaneous Resorption of a Penetrating Orbital Bone Fracture Fragment. Ophthalmic Plast Reconstr Surg. 2015 Sep-Oct; 31(5):e123-5.
- Invasive fungal disease of the sinus and orbit: a comparison between mucormycosis and Aspergillus. Br J Ophthalmol. 2016 Feb; 100(2):184-8.
- Orbital Branch of the Infraorbital Artery: Further Characterization of an Important Surgical Landmark. Orbit. 2015; 34(4):212-5.
- CT-based measurements of the sphenoid trigone in different sex and race. Ophthalmic Plast Reconstr Surg. 2015 Mar-Apr; 31(2):155-8.
- External Versus Endoscopic Endonasal Dacryocystorhinostomy. Int Ophthalmol Clin. 2015; 55(4):51-62.
- Iatrogenic inferior oblique palsy: intentional disinsertion during transcaruncular approach to orbital fracture repair. J AAPOS. 2014 Oct; 18(5):511-4.
- A Case Series and Review of Bisphosphonate-associated Orbital Inflammation. Ocul Immunol Inflamm. 2016; 24(2):134-9.
- Cellular neurothekeoma of the eyelid: a unique internal palpebral presentation. Ophthalmic Plast Reconstr Surg. 2014 Jul-Aug; 30(4):e91-2.
- Microdebrider use in orbital surgery. Orbit. 2014 Jun; 33(3):189-92.
- Papillary hidradenoma of the eyelid margin: clinical and immunohistochemical observations further supporting an apocrine rather than an eccrine origin. Surv Ophthalmol. 2014 Sep-Oct; 59(5):540-7.
- Endoscopic orbital floor decompression with preservation of the inferomedial strut. Int Forum Allergy Rhinol. 2014 Jan; 4(1):82-4.
- Gaze-evoked amaurosis from orbital breast carcinoma metastasis. Ophthalmic Plast Reconstr Surg. 2013 Jul-Aug; 29(4):e98-e101.
- A cross-sectional survey of the association between bilateral topical prostaglandin analogue use and ocular adnexal features. PLoS One. 2013; 8(5):e61638.
- Endogenous panophthalmitis with orbital cellulitis secondary to Escherichia coli. Clin Exp Ophthalmol. 2013 Sep-Oct; 41(7):716-8.
- Diagnosis and treatment of penetrating orbital cranial foreign body injuries. Digit J Ophthalmol. 2012; 18(4):9-11.
- Update on imaging of the lacrimal drainage system. Semin Ophthalmol. 2012 Sep-Nov; 27(5-6):175-86.
- An enzyme-mediated assay to quantify inoculation volume delivered by suture needlestick injury: two gloves are better than one. J Am Coll Surg. 2008 Jan; 206(1):113-22.
- A new modified technique for heterotopic femoral heart transplantation in rats. J Surg Res. 2007 May 15; 139(2):157-63.
- Pulse doppler and M-mode to assess viability of cardiac allografts using heterotopic femoral heart transplantation in rats. Microsurgery. 2007; 27(4):240-4.
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