Research Area Affiliations
Hearing and Deafness
Dr. Kozin has a broad research background in a variety of disciplines, including wound healing, auditory neuroprosthetics and clinical otology. As a researcher at the University of Pennsylvania and Children’s Hospital of Philadelphia, Dr. Kozin spent two years investigating the use of gene therapy to improve wound healing. While pursuing his medical doctorate, Dr. Kozin studied the role of non-muscle myosin II (NMMII), which is integral to epithelial apical junctions in the organ of Corti. His research on NMMII took place at an intramural National Institute of Deafness and Other Communication Disorders laboratory as part of the National Institutes of Health (NIH) - Howard Hughes Medical Institute Research Scholars program. He recently completed two years of dedicated post-doctoral training as part of an NIH T32 grant in the Eaton-Peabody Laboratories at Massachusetts Eye and Ear. At Mass. Eye and Ear, Dr. Kozin investigated optogenetic-based cochlear and auditory brainstem implants, as well as conducted clinical research on auditory neuroprosthetics. Most recently, he has combined his research and clinical interests in wound repair, bioprosthetics and hearing loss to address the application of 3D printing to middle and inner ear disease.
Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation. Gordon A*, Kozin ED*, Keswani SG*, Vaikunth SS, Katz AB, Zoltick PW, Favata M, Radu AP, Soslowsky LJ, Herlyn M, Crombleholme TM. Wound Repair Regen. 2008 Jan-Feb; 16(1):70-9. [PMID: 18086289] (*Co-first author.)
Optogenetic stimulation of the cochlear nucleus using channelrhodopsin-2 evokes activity in the central auditory pathways. Darrow KN, Slama MC, Kozin ED, Owoc M, Hancock K, Kempfle J, Edge A, Lacour S, Boyden E, Polley D, Brown MC, Lee DJ. Brain Res. 2015 Mar 2; 1599:44-56. [PMID: 25481416]
Superior temporal resolution of Chronos versus channelrhodopsin-2 in an optogenetic model of the auditory brainstem implant. Hight AE*, Kozin ED*, Darrow K, Lehmann A, Boyden E, Brown MC, Lee DJ. Hear Res. 2015 Apr; 322:235-41. PMID: [25598479.] (*Co-first author.)
Direct visualization of the murine dorsal cochlear nucleus for optogenetic stimulation of the auditory pathway. Kozin ED, Darrow KN, Hight AE, Lehmann AE, Kaplan AB, Brown MC, Lee DJ. J Vis Exp. 2015; (95). [PMID: 25650555]
Three-Dimensional Printed Prosthesis for Repair of Superior Canal Dehiscence. Kozin ED, Remenschneider AK, Cheng S, Nakajima HH, Lee DJ. Otolaryngol Head Neck Surg. 2015 Jul 6.[PMID: 26150379]
View a complete list of publications on pubmed.gov.