Sarah Melissa P. Jacobo, Ph.D.

Research Summary

Research Summary

Dr. Jacobo's research interests include AMD, functional genetics, and protein structure-function relationships.

Selected Publications

Jacobo SM, Deangelis MM, Kim IK, Kazlauskas A. Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol. 2013 May;33(10):1976-90

Jacobo SM, Guerra ML, Jarrard RE, Przybyla JA, Liu G, Watts VJ, Hockerman GH. The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts. J Pharmacol Exp Ther. 2009 Jul;330(1):283-93. 

Tian D*, Jacobo SM*, Billing D, Rozkalne A, Gage SD, Anagnostou T, Pavenstädt H, Pavenstaedt H, Hsu HH, Schlondorff J, Ramos A, Greka A. (2010). Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal3(145):ra77. (*The authors contributed equally to this work).

Jegla T, Marlow HQ, Chen B, Simmons DK, Jacobo SM, Martindale MQ. (2012). Expanded functional diversity of shaker K+ channels in cnidarians is driven by gene expansion. PLoS One.7(12):e51366.


Awards and Honors

2012: Knights Templar Eye Foundation Early-Career Award

2014: BrightFocus Foundation Macular Degeneration Award

2014: Juvenile Diabetes Research Foundation Advanced Postdoctoral Fellowship

2014: Best Scientific Paper of 2013, Schepens Eye Research Institute of Mass. Eye and Ear

2014: Gragoudas Prize for Basic and Translational Retina Research, Mass. Eye and Ear

2014: National Eye Institute Travel Award

2015: Hot Topic Abstract, Association of Ocular Pharmacology and Therapeutics (AOPT) Annual Meeting, Charleston, SC

2015: Hot Topic Abstract, Association for Researchers in Vision and Ophtahlmology (ARVO) Week, Denver, CO