John J. Guinan, Jr., Ph.D.

Harvard Medical School

Professor of Otolaryngology

Harvard–MIT Division of Health Sciences and Technology

Professor of Health Sciences and Technology

Massachusetts Eye and Ear

Senior Scientist

Research Summary

Research Area Affiliations

Research Summary

Dr. Guinan’s primary research interest is in the area of auditory physiology. In particular, he studies cochlear mechanics, the effects of the olivocochlear efferent pathways of the cochlea, and how they affect human psychophysical performance. He is also interested in the methodology for clinical measurement of vestibular evoked myogenic potentials (VEMPs).

His work has provided a new concept of how the output of the cochlea is produced by the mechanical motions within the cochlea: the inner hair cell stereocilia are driven by several separate cochlear mechanical vibration patterns.

Select Publications

Middle-ear characteristics of anesthetized cats. Guinan, J.J., Jr., Peake, W.T. 1967. J Acoust Soc Am 41, 1237-1261.

Single auditory units in the superior olivary complex II: locations of unit categories and tonotopic organization. Guinan, J.J., Jr., Norris, B.E., Guinan, S.S. 1972. Intern. J. Neurosci. 4, 147-166.

Efferent innervation of the organ of Corti: two separate systems. Warr, W.B., Guinan, J.J., Jr. 1979. Brain Res. 173, 152-155.

Differential olivocochlear projections from lateral vs. medial zones of the superior olivary complex. Guinan, J.J., Jr., Warr, W.B., Norris, B.E. 1983. J Comp Neurol 221, 358-370.

Acoustically-Responsive Fibers in the Vestibular Nerve of the Cat. McCue, M.P., Guinan, J.J., Jr. 1994. J. Neurosci. 14, 6058-6070.

Evoked otoacoustic emissions arise by two fundamentally different mechanisms: A taxonomy for mammalian OAEs. Shera, C.A., Guinan, J.J., Jr. 1999. J. Acoust. Soc. Am. 105, 782-798.

Revised estimates of human cochlear tuning from otoacoustic and behavioral measurements. Shera, C.A., Guinan, J.J., Jr., Oxenham, A.J. 2002. Proceedings of the National Academy of Sciences of the United States of America 99, 3318-3323.

Medial-olivocochlear-efferent inhibition of the first peak of auditory-nerve responses: Evidence for a new motion within the cochlea. Guinan, J.J., Jr., Lin, T., Cheng, H. 2005. J Acoust Soc Am 118, 2421-2433.

Frequency tuning of medial-olivocochlear-efferent acoustic reflexes in humans as functions of probe frequency. Lilaonitkul, W., Guinan, J.J., Jr. 2012. J. Neurophysiol 107, 1598-1611.

How are inner hair cells stimulated? Evidence for multiple mechanical drives. Guinan, J.J., Jr. 2012. Hear Res 292, 35-50.


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Biosketch

Education

B.S. Electrical Engineering, Massachusetts Institute of Technology, 1963
Ph.D. Communications Biophysics, Massachusetts Institute of Technology, 1968

Postgraduate Training

Research Fellowship, Synaptic Physiology, University College, London, UK, 1972-1974

Professional Memberships

1960-1968    Institute of Electronic and Electrical Engineers    Member
1964-present    American Association for the Advancement of Science    Member
1964-2003    Acoustical Society of America    Member
2003-present    Acoustical Society of America    Fellow
1980-present    Society for Neuroscience    Member
1988-present    Association for Research in Otolaryngology    Member

Advisory Boards

Hearing Research, Editorial Board (1997-Present)

Teaching Activity

“Physiology of the Ear,” Harvard–MIT Program in Health Sciences and Technology
“Neural Coding and Perception of Sound,” Harvard–MIT Program in Health Sciences and Technology

Awards and Honors

2002    Irving M. London Teaching Award, Harvard University – Massachusetts Institute of Technology, Division of Health Sciences and Technology
2007    American Auditory Society Editor’s Award for the best paper in Ear and Hearing, Volume 27, 2006