Research Area Affiliations
Dr. Guinan’s primary research interest is in the area of auditory physiology. In particular, he studies cochlear mechanics, the effects of the olivocochlear efferent pathways of the cochlea, and how they affect human psychophysical performance. He is also interested in the methodology for clinical measurement of vestibular evoked myogenic potentials (VEMPs).
His work has provided a new concept of how the output of the cochlea is produced by the mechanical motions within the cochlea: the inner hair cell stereocilia are driven by several separate cochlear mechanical vibration patterns.
Middle-ear characteristics of anesthetized cats. Guinan, J.J., Jr., Peake, W.T. 1967. J Acoust Soc Am 41, 1237-1261.
Single auditory units in the superior olivary complex II: locations of unit categories and tonotopic organization. Guinan, J.J., Jr., Norris, B.E., Guinan, S.S. 1972. Intern. J. Neurosci. 4, 147-166.
Efferent innervation of the organ of Corti: two separate systems. Warr, W.B., Guinan, J.J., Jr. 1979. Brain Res. 173, 152-155.
Differential olivocochlear projections from lateral vs. medial zones of the superior olivary complex. Guinan, J.J., Jr., Warr, W.B., Norris, B.E. 1983. J Comp Neurol 221, 358-370.
Acoustically-Responsive Fibers in the Vestibular Nerve of the Cat. McCue, M.P., Guinan, J.J., Jr. 1994. J. Neurosci. 14, 6058-6070.
Evoked otoacoustic emissions arise by two fundamentally different mechanisms: A taxonomy for mammalian OAEs. Shera, C.A., Guinan, J.J., Jr. 1999. J. Acoust. Soc. Am. 105, 782-798.
Revised estimates of human cochlear tuning from otoacoustic and behavioral measurements. Shera, C.A., Guinan, J.J., Jr., Oxenham, A.J. 2002. Proceedings of the National Academy of Sciences of the United States of America 99, 3318-3323.
Medial-olivocochlear-efferent inhibition of the first peak of auditory-nerve responses: Evidence for a new motion within the cochlea. Guinan, J.J., Jr., Lin, T., Cheng, H. 2005. J Acoust Soc Am 118, 2421-2433.
Frequency tuning of medial-olivocochlear-efferent acoustic reflexes in humans as functions of probe frequency. Lilaonitkul, W., Guinan, J.J., Jr. 2012. J. Neurophysiol 107, 1598-1611.
How are inner hair cells stimulated? Evidence for multiple mechanical drives. Guinan, J.J., Jr. 2012. Hear Res 292, 35-50.
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