About My Research
Center/Research Area Affiliations
Biography
Dr. Greiner has contributed to the discovery, naming, and elucidation of two pathological disorders of the ocular surface: giant papillary conjunctivitis (GPC) and lid wiper epitheliopathy (LWE), as well as the etiology of keratoconus and a cure for filamentary keratitis. Additionally, Dr. Greiner and his collaborators developed a patented, long-acting oil-in-water eye drop for the treatment of evaporative dry eye disease. Currently, at Schepens Eye Research Institute of Mass Eye and Ear, he is working on a number of projects addressing dry eye disease and meibomian gland dysfunction (MGD), including:
- The identification and treatment of LWE in both the upper and lower eyelids and its association with dry eye symptoms
- Developing techniques to quantitatively and qualitatively assess the tearfilm, particularly the lipid layer
- The validation of the long-term therapeutic benefits of thermal pulsation system treatment and manual lid expression for MGD
Early Career
Dr. Greiner joined the Howe Laboratory at Massachusetts Eye and Ear in 1974 for postdoctoral training under Dr. Leo Chylack in the field of cataract development. This was followed by an additional postdoctoral fellowship at the Eye Research Institute (ERI) with Drs. Mathea Allansmith and Claes H. Dohlman to explore ocular surface diseases, particularly those related to allergy and contact lens wear. During that time, Dr. Greiner began a lifelong collaboration with optometrist/scientist Dr. Donald Korb, a leader in the field of contact lens-associated ocular surface disorders, while simultaneously completing his OD degree from the New England College of Optometry. The collaboration with Drs. Allansmith and Korb resulted in the discovery of the condition known as Giant Papillary Conjunctivitis (GPC) as well as treatment options for this disorder.
In 1978, as a medical student at Midwestern University in Chicago, Dr. Greiner founded and became co-director of an NIH-funded research laboratory and began his ongoing collaboration with physicist Dr. Thomas Glonek to apply magnetic resonance spectroscopic (MRS) techniques to the study of the biochemistry of ocular tissues in health and disease. He continued this research program, as well as the long-distance collaboration with Dr. Allansmith at ERI, after graduating from medical school and while completing an internship in Internal Medicine at Cook County Hospital in Chicago and a residency in Ophthalmology at Georgetown University Medical Center with Dr. Michael Lemp.
Dr. Greiner returned to Boston in 1986 as a Clinical Fellow in Cornea with Drs. Kenneth Kenyon and Claes Dohlman at Mass Eye and Ear. During this time, Dr. Greiner collaborated with Drs. Glonek and Korb to develop a patented eye drop to provide exceptional long-term (24 hr) relief from dry eye symptoms. Currently, Dr. Greiner serves as Director of an ophthalmology practice with subspecialty in cornea and external diseases and continues his research focus on dry eye diseases through ongoing collaborations with investigators in multiple disciplines. His research goal is to expand our basic understanding of ocular surface and dry eye diseases and to develop highly efficacious treatments for these conditions.
Education
MS, Purdue University (1974)
PhD, University of Toledo and the Medical University of Ohio (1975)
OD, New England College of Optometry (1978)
DO, Midwestern University, Chicago College of Osteopathic Medicine (1982)
Postgraduate Training
Postdoctoral Fellowship in Research and Teaching, Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear (1975-1976)
Research Fellowship, Cornea Research, Schepens Eye Research Institute (1976-1978)
Internship, Department of Internal Medicine, Cook County Hospital (1982-1983)
Residency, Department of Ophthalmology, Georgetown University Medical Center (1883-1986)
Clinical Fellowship, Cornea Service, Massachusetts Eye and Ear (1986-1988)
Honors
2017: Dr. E.O. Martin Award (medal), American Association of Physician Specialists
2015: Distinguished Career of Excellence in Ophthalmology, Hallmark Health System
2003: Physician of the Year, American Academy of Specialists in Surgery
2001: Achievement Award, American Academy of Ophthalmology
1998: Distinguished Practitioner (medal), National Academies of Practice
1976: National Research Service Award, National Eye Institute
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- Guidelines for Reopening a Nation in a SARS-CoV-2 Pandemic: A Path Forward. Medicina (Kaunas). 2021 May 14; 57(5).
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- Guidelines: Discharge Instructions for Covid-19 Patients. J Prim Care Community Health. 2021 Jan-Dec; 12:21501327211024400.
- SARS-CoV-2 safety guidelines for frontline nurses. Nursing. 2020 Dec 21.
- Antimicrobial Photodynamic Therapy as a Potential Treatment Against COVID-19: A Case for Blue Light. Photobiomodul Photomed Laser Surg. 2020 10; 38(10):577-578.
- A Comparison of Efficacy and Safety of Two Lipid-Based Lubricant Eye Drops for the Management of Evaporative Dry Eye Disease. Clin Ophthalmol. 2020; 14:1665-1673.
- Corneal Cryopreservation Using Glycerylphosphorylcholine-Enriched Medium. Cornea. 2020 Mar; 39(3):370-375.
- Corneal absorption of glycerylphosphorylcholine. Exp Eye Res. 2020 03; 192:107932.
- Guidelines for Frontline Health Care Staff Safety for COVID-19. J Prim Care Community Health. 2020 Jan-Dec; 11:2150132720938046.
- Modalities to Disseminate Guidelines for Frontline Health Care Staff Safety for COVID-19. J Prim Care Community Health. 2020 Jan-Dec; 11:2150132720967205.
- Hydrotropic function of ATP in the crystalline lens. Exp Eye Res. 2020 01; 190:107862.
- Effects of Omega-3 Supplementation on Exploratory Outcomes in the Dry Eye Assessment and Management Study. Ophthalmology. 2020 01; 127(1):136-138.
- Meesmann epithelial corneal dystrophy: recurrence following photorefractive keratectomy. Can J Ophthalmol. 2017 12; 52(6):e211-e213.
- Long-Term (3 Year) Effects of a Single Thermal Pulsation System Treatment on Meibomian Gland Function and Dry Eye Symptoms. Eye Contact Lens. 2016 Mar; 42(2):99-107.
- A multicenter evaluation of the efficacy and duration of action of alcaftadine 0.25% and olopatadine 0.2% in the conjunctival allergen challenge model. J Asthma Allergy. 2013; 6:43-52.
- Long-term (12-month) improvement in meibomian gland function and reduced dry eye symptoms with a single thermal pulsation treatment. Clin Exp Ophthalmol. 2013 Aug; 41(6):524-30.
- A new system, the LipiFlow, for the treatment of meibomian gland dysfunction. Cornea. 2012 Apr; 31(4):396-404.
- A single LipiFlow® Thermal Pulsation System treatment improves meibomian gland function and reduces dry eye symptoms for 9 months. Curr Eye Res. 2012 Apr; 37(4):272-8.
- The lid wiper and muco-cutaneous junction anatomy of the human eyelid margins: an in vivo confocal and histological study. J Anat. 2011 Apr; 218(4):449-61.
- Evaluation of alcaftadine 0.25% ophthalmic solution in acute allergic conjunctivitis at 15 minutes and 16 hours after instillation versus placebo and olopatadine 0.1%. Clin Ophthalmol. 2011 Jan 13; 5:87-93.
- Prevalence of lid wiper epitheliopathy in subjects with dry eye signs and symptoms. Cornea. 2010 Apr; 29(4):377-83.
- The relationship between dry eye symptoms and lipid layer thickness. Cornea. 2009 Aug; 28(7):789-94.
- Inner eyelid surface temperature as a function of warm compress methodology. Optom Vis Sci. 2008 Aug; 85(8):675-83.
- Nilotinib hampers the proliferation and function of CD8+ T lymphocytes through inhibition of T cell receptor signalling. J Cell Mol Med. 2008 Oct; 12(5B):2107-18.
- Warm compress induced visual degradation and Fischer-Schweitzer polygonal reflex. Optom Vis Sci. 2007 Jul; 84(7):580-7.
- Efficacy and comfort of olopatadine 0.2% versus epinastine 0.05% ophthalmic solution for treating itching and redness induced by conjunctival allergen challenge. Curr Med Res Opin. 2007 Jun; 23(6):1445-52.
- The effect of two novel lubricant eye drops on tear film lipid layer thickness in subjects with dry eye symptoms. Optom Vis Sci. 2005 Jul; 82(7):594-601.
- A comparison of the clinical efficacy of pheniramine maleate/naphazoline hydrochloride ophthalmic solution and olopatadine hydrochloride ophthalmic solution in the conjunctival allergen challenge model. Clin Ther. 2005 May; 27(5):568-77.
- Lid wiper epitheliopathy and dry eye symptoms. Eye Contact Lens. 2005 Jan; 31(1):2-8.
- Comparative efficacy of olopatadine 0.1% ophthalmic solution versus levocabastine 0.05% ophthalmic suspension using the conjunctival allergen challenge model. Curr Med Res Opin. 2004 Dec; 20(12):1953-8.
- Corneal epithelial adhesion abnormalities associated with LASIK. Ophthalmology. 2004 Jan; 111(1):11-7.
- Efficacy and safety of ketotifen fumarate 0.025% in the conjunctival antigen challenge model of ocular allergic conjunctivitis. Am J Ophthalmol. 2003 Dec; 136(6):1097-105.
- A placebo-controlled comparison of ketotifen fumarate and nedocromil sodium ophthalmic solutions for the prevention of ocular itching with the conjunctival allergen challenge model. Clin Ther. 2003 Jul; 25(7):1988-2005.
- Increase in tear film lipid layer thickness following treatment with warm compresses in patients with meibomian gland dysfunction. Eye Contact Lens. 2003 Apr; 29(2):96-9.
- Correlation of lipid layer thickness measurements with fluorescein tear film break-up time and Schirmer's test. Eye (Lond). 2003 Jan; 17(1):79-83.
- Lid-wiper epitheliopathy and dry-eye symptoms in contact lens wearers. CLAO J. 2002 Oct; 28(4):211-6.
- Quantitative in vitro comparison of fluorescein delivery to the eye via impregnated paper strip and volumetric techniques. Optom Vis Sci. 2002 Jul; 79(7):435-8.
- Single dose of ketotifen fumarate .025% vs 2 weeks of cromolyn sodium 4% for allergic conjunctivitis. Adv Ther. 2002 Jul-Aug; 19(4):185-93.
- Effects of fluorescein instillation methods on the tear film lipid layer. Adv Exp Med Biol. 2002; 506(Pt A):507-12.
- The effects of anionic and zwitterionic phospholipids on the tear film lipid layer. Adv Exp Med Biol. 2002; 506(Pt A):495-9.
- Comparison of fluorescein break-up time measurement reproducibility using standard fluorescein strips versus the Dry Eye Test (DET) method. Cornea. 2001 Nov; 20(8):811-5.
- Comparison of the clinical efficacy and comfort of olopatadine hydrochloride 0.1% ophthalmic solution and nedocromil sodium 2% ophthalmic solution in the human conjunctival allergen challenge model. Clin Ther. 2000 Dec; 22(12):1462-72.
- Effects of eyelid scrubbing on the lid margin. CLAO J. 1999 Apr; 25(2):109-13.
- Epidermal and dermal phospholipids of the human eyelid: a 31P nuclear magnetic resonance spectroscopy study. Arch Dermatol Res. 1998 Jun; 290(6):298-305.
- Human and rabbit lipid layer and interference pattern observations. Adv Exp Med Biol. 1998; 438:305-8.
- Effect of meibomian gland occlusion on tear film lipid layer thickness. Adv Exp Med Biol. 1998; 438:345-8.
- Volume of the human and rabbit meibomian gland system. Adv Exp Med Biol. 1998; 438:339-43.
- Fluorescein dye concentration as a factor in tear film fluorescence. Adv Exp Med Biol. 1998; 438:875-8.
- Ex vivo phosphorus magnetic resonance spectroscopy on eye bank corneas and corneal metabolic health. Graefes Arch Clin Exp Ophthalmol. 1997 Nov; 235(11):691-5.
- Histopathology of the ocular surface after eye rubbing. Cornea. 1997 May; 16(3):327-32.
- Meibomian gland phospholipids. Curr Eye Res. 1996 Apr; 15(4):371-5.
- Tear film lipid layer formation: implications for contact lens wear. Optom Vis Sci. 1996 Mar; 73(3):189-92.
- Effect of periocular humidity on the tear film lipid layer. Cornea. 1996 Mar; 15(2):129-34.
- Phospholipids in meibomian gland secretion. Ophthalmic Res. 1996; 28(1):44-9.
- Interspecies comparisons of lens phospholipids. Curr Eye Res. 1995 Oct; 14(10):937-41.
- Distribution of membrane phospholipids in the rabbit neural retina, optic nerve head and optic nerve. Int J Biochem Cell Biol. 1995 Jan; 27(1):21-8.
- The effects of age on phosphatic metabolites of the human cornea. Cornea. 1995 Jan; 14(1):89-94.
- Distribution of membrane phospholipids in the rabbit uvea. Ophthalmic Res. 1995; 27(5):277-85.
- Distribution of membrane phospholipids in the crystalline lens. Invest Ophthalmol Vis Sci. 1994 Sep; 35(10):3739-46.
- Tear film lipid layer thickness as a function of blinking. Cornea. 1994 Jul; 13(4):354-9.
- The effect of hEGF and insulin on corneal metabolism during Optisol storage. Cornea. 1994 May; 13(3):243-9.
- Increase in tear film lipid layer thickness following treatment of meibomian gland dysfunction. Adv Exp Med Biol. 1994; 350:293-8.
- Phospholipid analysis of mammalian optic nerve tissue: a 31P nuclear magnetic resonance spectroscopic study. Ophthalmic Res. 1994; 26(5):264-74.
- Metabolic compatibility of abattoir and human corneas: an ex vivo 31P nuclear magnetic resonance spectroscopic study of intact tissues. Cornea. 1993 Nov; 12(6):461-5.
- Comparative histogenesis of Bruch's membrane (complexus basalis). Exp Eye Res. 1991 Jul; 53(1):47-54.
- Phosphatic metabolism and corneal edema. Cornea. 1991 Jul; 10(4):346-53.
- The effects of age on phosphatic metabolites of the human crystalline lens. Exp Eye Res. 1991 Jun; 52(6):641-6.
- Phosphatic intermediate metabolites of the porcine ocular tunica fibrosa. Exp Eye Res. 1991 Mar; 52(3):253-60.
- Human crystalline lens phospholipid analysis with age. Invest Ophthalmol Vis Sci. 1991 Mar; 32(3):549-55.
- Membrane phospholipids of the ocular tunica fibrosa. Invest Ophthalmol Vis Sci. 1991 Mar; 32(3):625-32.
- Comparison of phosphate metabolites of the ocular humors. Ophthalmic Res. 1991; 23(2):92-7.
- Comparison of membrane phospholipids of the rabbit and pig crystalline lens. Exp Eye Res. 1990 Mar; 50(3):235-40.
- Intralenticular water interactions with phosphates in the intact crystalline lens. Ophthalmic Res. 1990; 22(5):302-9.
- Phosphatic metabolites in keratoconus. Exp Eye Res. 1989 Nov; 49(5):799-806.
- Interspecies analysis of corneal phosphate metabolites. Exp Eye Res. 1989 Oct; 49(4):523-9.
- Noninvasive metabolic analysis of eye bank corneas: a magnetic resonance spectroscopic study. Graefes Arch Clin Exp Ophthalmol. 1989; 227(3):295-9.
- pH of organ-culture-stored corneas. Acta Ophthalmol (Copenh). 1988 Oct; 66(5):538-43.
- Effects of the slow calcium-channel blocker verapamil on phosphatic metabolism of crystalline lens. Exp Eye Res. 1988 Feb; 46(2):139-48.
- Papillary conjunctivitis induced by an epithelialized corneal foreign body. Ophthalmologica. 1988; 196(2):82-6.
- Effects of moist-chamber and McCarey-Kaufman medium storage on the metabolic status of the cornea: a 31P-magnetic resonance analysis. Ophthalmic Res. 1988; 20(6):368-75.
- Magnetic resonance imaging of ocular tissues. Ann Ophthalmol. 1987 Apr; 19(4):123-6, 128.
- Preoperative metabolic analysis of donor corneas using magnetic resonance spectroscopy. Cornea. 1987; 6(3):185-9.
- Phosphorus nuclear magnetic resonance and ocular metabolism. Surv Ophthalmol. 1985 Nov-Dec; 30(3):189-202.
- Effects of eye rubbing on the conjunctiva as a model of ocular inflammation. Am J Ophthalmol. 1985 Jul 15; 100(1):45-50.
- Distribution of phosphatic metabolites in the crystalline lens. Invest Ophthalmol Vis Sci. 1985 Apr; 26(4):537-44.
- Distribution of phosphatic metabolites in the porcine cornea using phosphorus-31 nuclear magnetic resonance. Exp Eye Res. 1985 Mar; 40(3):335-42.
- Lenticular energy metabolism during exogenous calcium deprivation and during recovery: effects of dextran-40. Exp Eye Res. 1985 Feb; 40(2):169-78.
- Histochemical analysis of secretory vesicles in nongoblet conjunctival epithelial cells. Acta Ophthalmol (Copenh). 1985 Feb; 63(1):89-92.
- Phosphorus-31 NMR analysis of dynamic energy metabolism in intact crystalline lens treated with ouabain: phosphorylated metabolites. Ophthalmic Res. 1985; 17(5):269-78.
- Metabolic status of fresh v eye-bank-processed corneas. A phosphorus nuclear magnetic resonance study. Arch Ophthalmol. 1984 Nov; 102(11):1676-7.
- Mononuclear and IgA-containing cells in the lacrimal gland of germ-free and conventional rats. Exp Eye Res. 1984 Nov; 39(5):575-81.
- Ex vivo metabolic analysis of eye bank corneas using phosphorus nuclear magnetic resonance. Arch Ophthalmol. 1984 Aug; 102(8):1171-3.
- Nondestructive metabolic analysis of a cornea with the use of phosphorus nuclear magnetic resonance. Arch Ophthalmol. 1984 May; 102(5):770-1.
- Histology of the ferret retina. Anat Anz. 1984; 157(5):329-41.
- Biomicroscopy of papillae associated with wearing of soft contact lenses. Br J Ophthalmol. 1983 Nov; 67(11):733-6.
- Phosphatic metabolites of the intact cornea by phosphorus-31 nuclear magnetic resonance. Invest Ophthalmol Vis Sci. 1983 May; 24(5):535-42.
- Dynamic changes in intact crystalline lens metabolism modulated by alkaline earth metals: I. Effects of magnesium. Exp Eye Res. 1983 Mar; 36(3):327-35.
- Treatment of contact lenses with papain. Increase in wearing time in keratoconic patients with papillary conjunctivitis. Arch Ophthalmol. 1983 Jan; 101(1):48-50.
- Pericentriolar processes of photoreceptor cell basal bodies in the mammalian retina. Z Mikrosk Anat Forsch. 1983; 97(2):309-18.
- Human ocular mucus. Scanning electron microscopic study. Arch Ophthalmol. 1982 Oct; 100(10):1614-7.
- Dynamic changes in the organophosphate profile upon treatment of the crystalline lens with dexamethasone. Invest Ophthalmol Vis Sci. 1982 Jul; 23(1):14-22.
- Langerhans cells of the ocular surface. Ophthalmology. 1982 Jun; 89(6):700-11.
- Embryogenesis of the rabbit retina. Exp Eye Res. 1982 May; 34(5):749-65.
- Dynamic changes in the organophosphate profile of the experimental galactose-induced cataract. Invest Ophthalmol Vis Sci. 1982 May; 22(5):613-24.
- Organophosphate metabolites of the human and rabbit crystalline lens: a phosphorus-31 nuclear magnetic resonance spectroscopic analysis. Exp Eye Res. 1982 Apr; 34(4):545-52.
- Interspecies variations in mammalian lens metabolites as detected by phosphorus-31 nuclear magnetic resonance. Science. 1982 Mar 26; 215(4540):1622-5.
- Cell surface variations of the human upper tarsal conjunctiva. Ann Ophthalmol. 1982 Mar; 14(3):288-90.
- Goblet cells of the human conjunctiva. Arch Ophthalmol. 1981 Dec; 99(12):2190-7.
- Organophosphates of the crystalline lens: a nuclear magnetic resonance spectroscopic study. Invest Ophthalmol Vis Sci. 1981 Nov; 21(5):700-13.
- Biomicroscopy of papillae associated with hard contact lens wearing. Ophthalmology. 1981 Nov; 88(11):1132-6.
- Ciliogenesis in photoreceptor cells of the retina. Exp Eye Res. 1981 Oct; 33(4):433-46.
- Histogenesis of the ferret retina. Exp Eye Res. 1981 Sep; 33(3):315-32.
- Effect of contact lens wear on the conjunctival mucous system. Ophthalmology. 1981 Aug; 88(8):821-32.
- Analysis of intact rat lens metabolites by P-31 NMR spectroscopy. Curr Eye Res. 1981; 1(7):375-80.
- Mucus secretory vesicles in conjunctival epithelial cells of wearers of contact lenses. Arch Ophthalmol. 1980 Oct; 98(10):1843-6.
- Prevalence of conjunctival changes in wearers of hard contact lenses. Am J Ophthalmol. 1980 Sep; 90(3):336-41.
- Branching of microvilli in the human conjunctival epithelium. Arch Ophthalmol. 1980 Jul; 98(7):1253-5.
- Histologic and immunohistologic comparison of main and accessory lacrimal tissue. Am J Ophthalmol. 1980 May; 89(5):724-30.
- Histogenesis of the cat retina. Exp Eye Res. 1980 Apr; 30(4):439-53.
- Soft contact lenses from patients with giant papillary conjunctivitis. Am J Ophthalmol. 1979 Dec; 88(6):1056-61.
- The immunopathology of Mooren's ulcer. Am J Ophthalmol. 1979 Aug; 88(2):149-59.
- Vernal conjunctivitis and contact lens-associated giant papillary conjunctivitis compared and contrasted. Am J Ophthalmol. 1979 Apr; 87(4):544-55.
- Number of type of inflammatory cells in conjunctiva of asymptomatic contact lens wearers. Am J Ophthalmol. 1979 Feb; 87(2):171-4.
- Conjunctiva in asymptomatic contact lens wearers. Am J Ophthalmol. 1978 Sep; 86(3):403-13.
- Giant papillary conjunctivitis induced by hard or soft contact lens wear: quantitative histology. Ophthalmology. 1978 Aug; 85(8):766-78.
- Number of inflammatory cells in the normal conjunctiva. Am J Ophthalmol. 1978 Aug; 86(2):250-9.
- Development of the hamster retina: a morphologic study. Am J Vet Res. 1978 Apr; 39(4):665-70.
- Surface morphology of giant papillary conjunctivitis in contact lens wearers. Am J Ophthalmol. 1978 Feb; 85(2):242-52.
- Phacocryolysis and phacoemulsification. Am J Ophthalmol. 1977 Jun; 83(6):805-9.
- Surface morphology of the human upper tarsal conjunctiva. Am J Ophthalmol. 1977 Jun; 83(6):892-905.
- Giant papillary conjunctivitis in contact lens wearers. Am J Ophthalmol. 1977 May; 83(5):697-708.
- Letter: Photomacrography of the crystalline normal and cataractous lens. Exp Eye Res. 1976 Mar; 22(3):281-4.
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Identification and Characterization of Lid Wiper Epitheliopathy
Lid wiper epitheliopathy, a pathology of the distal eyelid, was first observed to occur in the upper eyelid margin. It was best observed with sodium fluorescein and Lissamine green vital staining in patients with dry eye conditions associated with meibomian gland dysfunction. Initial observations revealed that the greater the dysfunction, the greater the degree of vital staining. More recently, this epitheliopathy has been reported to occur not only in the upper eyelid, but also in the lower eyelid. This phenomenon is perplexing, especially when considering the upper and lower eyelid movements during blinking are very different. The association of this phenomenon and dry eye diseases is becoming more established, although this condition occurring in the lower eyelid remains unclear. Observational studies in patients with various degrees of dry eye disease are underway. It is expected that observational information should assist in revealing the etiology.
Thermal Pulsation System for Dry Eye Disease
Dr. Greiner found that a single treatment with a thermal pulsation system has long-term (nine-month) therapeutic benefits for patients with meibomian gland dysfunction, and subsequent studies demonstrate even longer term effects. His observational studies have led him to study why such long-term effects occur. The relationships among the signs and symptoms of dry eye disease have been shown to correlate with improvement of dry eye conditions following thermal pulsation system treatment, but there remain many signs that do not correlate with the treatment and the long-term results. Dr. Greiner's studies aim to discover why such correlations are not always present and why the signs and symptoms of conditions of dry eye disease are not always related.
Lipid Layer Thickness in Dry Eye Secondary to Meibomian Gland Dysfunction
Interferometric methods are used to measure the lipid layer thickness in both asymptomatic subjects and subjects with dry eye symptoms. Subject selection is made based not only on symptomatology, but also using meibomian gland assessment scores and other scored signs that are related to meibomian gland dysfunction since meibomian gland function can be related to the status of the tear film lipid layer. Presently, there is no accurate way of measuring the lipid layer since it is a dynamic layer that overlays the underlying aqueous layer of the tear film, which is in constant flux. Although current techniques can measure the lipid layer thickness over the cornea inferiorly, Dr. Greiner is interested in assessing changes in the lipid layer thickness over the visual axis in normal and disease states.
Current work is in collaboration with Dr. Marshall Doane, who has spent his career measuring ocular surface tear film phenomena.
Current Members of Dr. Jack V Greiner’s Laboratory
Clinical Coordinator and Laboratory Administrator
- Paula J. Oliver, AS
Research Associate
- Cynthia A. M. Greiner, PhD
Research Assistant
- Michael Lindsay, BS
Research Assistant
- Deidra, Soto, BS
Alumni
More than 24 trainees have worked in Dr. Greiner’s laboratory.