Meredith S. Gregory-Ksander, Ph.D.

Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Gregory-Ksander's research is focused in two areas: (1) elucidating the mechanisms of immune privilege by which the retina defends against pathogens and at the same time protects retinal tissue during infection; and (2) how age-related changes in immune privilege and subsequent inflammation contributes to the development of glaucoma and age-related macular degeneration. Dr. Gregory-Ksander has identified two critical mediators of ocular inflammation, Fas ligand and the NLRP3 inflammasome. Current studies in her laboratory focus on how these molecules mediate protective immunity and defense against pathogens and how age-related changes in these molecules may contribute to the development of inflammation associated with glaucoma and age-related macular degeneration.