Dr. Fan has dedicated his academic career to understanding the genetic basis of glaucoma and other eye disorders. He has fellowship training in Ophthalmology and in Statistical Genetics. He is experienced in analyzing large-scale genetic data, especially genome-wide association data and exome sequence data. His research has yielded 106 publications, which have been cited in more than 900 publications.
Dr. Fan is primarily interested in gene mapping for Mendelian diseases (e.g., pigment dispersion syndrome) and complex diseases (e.g., adult-onset glaucoma) using exome sequencing analysis, linkage analysis, association study, and gene expression study. He is also interested in analysis of gene-gene and gene-environment interactions in complex diseases. Currently, Dr. Fan has become involved in analysis of exome data for congenital glaucoma, juvenile-onset glaucoma, pigment dispersion syndrome and topiramate induced angle-closure glaucoma. He is also involved in identifying genetic loci for ocular quantitative traits using South Indian consanguineous pedigrees.
As a principle investigator, Dr. Fan has independently completed a study on interactions between genetic and environmental risk factors for primary open-angle glaucoma. He was a co-investigator of a study on identification of novel genetic loci for congenital cataract. Currently Dr. Fan is a PI for a project funded by the BrightFocus Foundation National Glaucoma Research Grant to discover genetic variants that contribute to pigment dispersion syndrome and pigmentary glaucoma. He is also a co-PI on a grant given by the Massachusetts Lions Eye Research Fund to develop a rare sequence variant database for visual disorder.