Baojian Fan, M.D., Ph.D.

Research Summary

Research Summary

Dr. Fan has dedicated his academic career to understanding the genetic basis of glaucoma and other eye disorders. He has fellowship training in Ophthalmology and in Statistical Genetics. He is experienced in analyzing large-scale genetic data, especially exome sequence data, genome-wide association data and phenome-wide association data. His research has yielded 115 publications, which have been cited in more than 2,117 publications (h-index: 28).

Dr. Fan is primarily interested in gene mapping for Mendelian diseases (e.g., pigment dispersion syndrome) and complex diseases (e.g., adult-onset glaucoma) using exome sequencing analysis, linkage analysis, association study, and gene expression study. He is also interested in analysis of gene-gene and gene-environment interactions in complex diseases. Currently, Dr. Fan has become involved in analysis of exome data for congenital glaucoma, juvenile-onset glaucoma, pigment dispersion syndrome and topiramate induced angle-closure glaucoma. He is also involved in identifying genetic loci for ocular quantitative traits using South Indian consanguineous pedigrees.

As a principle investigator, Dr. Fan has independently completed a study on interactions between genetic and environmental risk factors for primary open-angle glaucoma. He was a co-investigator of a study on identification of novel genetic loci for congenital cataract. He was also a co-PI on a grant given by the Massachusetts Lions Eye Research Fund to develop a rare sequence variant database for visual disorder. Currently Dr. Fan is a PI for a project funded by the BrightFocus Foundation National Glaucoma Research Grant to discover genetic variants that contribute to pigment dispersion syndrome and pigmentary glaucoma. He is also a co-investigator on a NIH R01 grant to identify genes for ocular quantitative traits related to glaucoma using whole genome sequencing of large consanguineous pedigrees.

Selected Publications

For a full publication list, please see his CV.

Fan BJ, Liu K, Wang DY, Tham CC, Tam PO, Lam DS, Pang CP. Association of polymorphisms of tumor necrosis factor and tumor protein p53 with primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 2010;51:4110-6.

Fan BJ, Wang DY, Pasquale LR, Haines JL, Wiggs JL. Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population. Invest Ophthalmol Vis Sci. 2011;52:1788-92.

Fan BJ, Pasquale LR, Kang JH, Levkovitch-Verbin H, Haines JL, Wiggs JL. Association of clusterin (CLU) variants and exfoliation syndrome: An analysis in two Caucasian studies and a meta-analysis. Exp Eye Res. 2015;139:115-22.

Chen X, Chen Y, Wiggs JL, Pasquale LR, Sun X, Fan BJ. Association of matrix metalloproteinase-9 (MMP9) variants with primary angle closure and primary angle closure glaucoma. PLoS One. 2016;11: e0157093.

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