Pablo Argüeso, Ph.D.
Associate Professor of Ophthalmology, Department of Ophthalmology
Dr. Argüeso conducts research in the fields of glycobiology and ophthalmology, focusing on the structure and function of mucins - highly O-glycosylated, high-molecular-weight glycoproteins that constitute a major component of the protective biofilm on all epithelial cell surfaces. His laboratory has developed innovative methods clearly demonstrating the importance of the glycan component of the epithelial cellsurface in maintaining the integrity of the mucosal barrier through interaction with carbohydrate-binding proteins.This work has opened up a new field of investigation to understand both ocular and non-ocular surface disease pathogenesis and find novel approaches to treatment using glycomics. Recently, he has been exploring the hypothesis that endomucins, membrane-tethered mucins in endothelial cells, modulate inflammation by regulating the physicochemical character of the luminal endothelial cell surface glycocalyx.