Pablo Argüeso, Ph.D.
Associate Professor of Ophthalmology, Department of Ophthalmology
Dr. Argüeso conducts research in the fields of glycobiology and ophthalmology, focusing on the structure and function of mucins - highly O-glycosylated, high-molecular-weight glycoproteins that constitute a major component of the protective biofilm on all epithelial cell surfaces. His laboratory has developed innovative methods clearly demonstrating the importance of the glycan component of the epithelial cellsurface in maintaining the integrity of the mucosal barrier through interaction with carbohydrate-binding proteins. This work has opened up a new field of investigation to understand both ocular and non-ocular surface disease pathogenesis and find novel approaches to treatment using glycomics. Recently, he has been exploring the hypothesis that endomucins, membrane-tethered mucins in endothelial cells, modulate inflammation by regulating the physicochemical character of the luminal endothelial cell surface glycocalyx.
Alteration of Galectin-3 in Tears of Patients With Dry Eye Disease. Uchino Y, Mauris J, Woodward AM, Dieckow J, Amparo F, Dana R, Mantelli F, Argüeso P. Am J Ophthalmol. 2015 Feb 19. pii: S0002-9394(15)00094-X. doi: 10.1016/j.ajo.2015.02.008. [Epub ahead of print]
Clinical staining of the ocular surface: mechanisms and interpretations. Bron AJ, Argüeso P, Irkec M, Bright FV. Prog Retin Eye Res. 2015 Jan;44:36-61.
Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia. Woodward AM, Argüeso P. Invest Ophthalmol Vis Sci. 2014 Aug 28;55(10):6132-8.
Alteration of tear mucin 5AC in office workers using visual display terminals: The Osaka Study. Uchino Y, Uchino M, Yokoi N, Dogru M, Kawashima M, Okada N, Inaba T, Tamaki S, Komuro A, Sonomura Y, Kato H, Argüeso P, Kinoshita S, Tsubota K. JAMA Ophthalmol. 2014 Aug;132(8):985-92.
Molecular basis for MMP9 induction and disruption of epithelial cell-cell contacts by galectin-3. Mauris J, Woodward AM, Cao Z, Panjwani N, Argüeso P. J Cell Sci. 2014 Jul 15;127(Pt 14):3141-8.
B.S. Chemistry, University of Valladolid, Spain
Ph.D. Biochemistry (cum laude), University of Valladolid, Spain
Research Fellowship, Institute for Cancer Research Department of Biochemistry The Norwegian Radium Hospital, Oslo, Norway
1998 - 2002
Research Fellowship, Schepens Eye Research Institute, Department of Ophthalmology Harvard Medical School
1996 - 1998
Lecturer, Department of Biochemistry, University of Valladolid, Valladolid, Spain
2003 - 2008
Instructor in Ophthalmology, Harvard Medical School
2008 - 2014
Assistant Professor of Ophthalmology, Harvard Medical School
Associate Professor of Ophthalmology, Harvard Medical School
1998 - 1999
Distinguished Collaborator University of Valladolid, Valladolid, Spain
Young Investigator Award, Tear Film and Ocular Surface Society, 23rd Biennial Cornea Research Conference, Boston, USA
Young Investigator Award, The International Society for Eye Research, The XVI International Congress of Eye Research, Sydney, Australia
Alice J. Adler Fellowship, Harvard Fellowships for Scholars in Medicine