Center/Research Area Affiliations
Dr. Dana conducts both basic and translational research in the field of corneal and transplantation immunology. His basic research is focused on the molecular and cellular regulation of ocular surface immunity. In particular, he is interested in the role of different cytokines and chemokines in induction of alloimmunity(transplantation) and autoimmunity (dry eye disease), as well as the function and regulation of regulatory T cells in maintaining immune homeostasis and tolerance. Dr. Dana's translational research has led to several successful physician-sponsored IND applications to the FDA and has focused on application of novel cytokine-based strategies for immune modulation. His research is supported by several NIH R01 and DOD grants.
Chen L, Hamrah P, Cursiefen C, Zhang Q, Pytowski B, Streilein JW, Dana MR. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. Nat Med. 2004 Aug;10(8):813-5. Epub 2004 Jul 4. PubMed PMID: 15235599.
Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, Pytowski B, Persaud K, Wu Y, Streilein JW, Dana R. Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11405-10. Epub 2006 Jul 18. PubMed PMID: 16849433; PubMed Central PMCID: PMC1544098.
Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol. 2009 Feb 1;182(3):1247-52. PubMed PMID: 19155469; PubMed Central PMCID: PMC2630586.
Lee HK, Chauhan SK, Kay E, Dana R. Flt-1 regulates vascular endothelial cell migration via a protein tyrosine kinase-7-dependent pathway. Blood. 2011 May 26;117(21):5762-71. doi: 10.1182/blood-2010-09-306928. Epub 2011 Apr 1. PubMed PMID: 21460247; PubMed Central PMCID: PMC3110033.
Amparo F, Dastjerdi MH, Okanobo A, Ferrari G, Smaga L, Hamrah P, Jurkunas U, Schaumberg DA, Dana R. Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial. JAMA Ophthalmol. 2013 Jun;131(6):715-23. doi: 10.1001/jamaophthalmol.2013.195. PubMed PMID: 23599118.
View Publications on Google Scholar >>