Patricia A D'Amore, Ph.D., MBA

Harvard Medical School

Charles L. Schepens Professor of Ophthalmology, Department of Ophthalmology
Co-Director, AMD Center of Excellence
Vice Chair for Basic Research

Schepens Eye Research Institute of Massachusetts Eye and Ear

Director of Research, Schepens Eye Research Institute of Massachusetts Eye and Ear
MGH ECOR Ophthalmology Representative
Senior Scientist

Research Summary

Center/Research Area Affiliations

Research Summary

Dr. D'Amore has contributed to the development of anti-angiogenic therapies for common neovascular eye diseases. Currently, she is working on five major projects in her laboratory: 1) the role of Notch signaling in the function and integrity of the adult retinal vasculature; 2) the role of vascular endothelial growth factor in the adult,which has important implications for wet age-related macular degeneration (AMD); 3) the role of the pericyte in vessel integrity and stability in the adult, and the relevance of pericyte loss to the pathogenesis of AMD; 4) the role of inflammasome-mediated RPE damage and inflammation in AMD; and 5) the role of endomucin in the regulation of angiogenesis and endothelial-leukocyte interactions.