Jason I. Comander, M.D., Ph.D.

Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Comander is the recipient of a K12 award to conduct research and treat patients under the mentorship of Drs. Eliot Berson and Eric Pierce. His research interests include understanding the molecular basisof retinal degenerations, such as retinitis pigmentosa, and pursuing therapies for these disorders. Currently, he is pursuing a gene discovery effort for pericentral retinitis pigmentosa using next generation sequencing. He is also developing new techniques to speed such characterization in the mammalian retina and is testing gene therapy techniques in primates.

Select Publications

For a full publication list, please see his CV.

Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. Mantopoulos D, Murakami Y, Comander J, Thanos A, Roh M, Miller JW, Vavvas DG. PLoS One. 2011; 6(9):e24245.

Diagnostic testing and disease monitoring in birdshot chorioretinopathy. Comander J, Loewenstein J, Sobrin L. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5): 329-36.

High-resolution optical coherence tomography findings in solar maculopathy and the differential diagnosis of outer retinal holes. Comander J, Gardiner M, Loewenstein J. Am J Ophthalmol. 2011 Sep; 152(3): 413-419.e6. 

Accommodating intraocular lenses: theory and practice. Comander J, Pineda R 2nd. Int Ophthalmol Clin. 2010 Winter; 50(1): 107-17.

Improving the statistical detection of regulated genes from microarray data using intensity-based variance estimation. Comander J, Natarajan S, Gimbrone MA Jr, García-Cardeña G. BMC Genomics. 2004 Feb 27;5(1): 17.

View a list of publications on pubmed.gov »



  • 1997: A.B., Harvard College
  • 2005: Ph.D., Experimental Pathology, Harvard Medical School
  • 2006: M.D., Harvard Medical School

Postgraduate Training

  • 2007: Fellowship/Internship, Medicine, Brigham & Women's Hospital
  • 2010: Residency, Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear
  • 2012: Clinical Fellowship, Vitreoretinal Surgery, Massachusetts Eye and Ear

Academic Appointments

  • 2012-present Instructor in Ophthalmology, Harvard Medical School

Professional Memberships

  • 1999-present: Member, Massachusetts Medical Society
  • 1999-present: Member, American Association for the Advancement of Science
  • 1991-1994, 2009-present: Member, Association for Research in Vision and Ophthalmology
  • 2002-2006: Member, National Association for Vascular Biology
  • 2007-present: Member, American Academy of Ophthalmology


  • 1993: Finalist, Presidential Scholars
  • 1997: John Harvard Scholarship
  • 1998: Medical Scientist Training Program Scholarship for M.D./Ph.D. Program at Harvard Medical School
  • 2005: Massachusetts Medical Society Information Technology Award
  • 2009: Attendee, Heed Foundation Retreat for Academic Ophthalmology
  • 2013: Research to Prevent Blindness Career Development Award