Jason I. Comander,
MD, PhD
Massachusetts Eye and Ear
Assistant Scientist
Harvard Medical School
Assistant Professor of Ophthalmology
jason_comander@meei.harvard.edu
For investigator inquiries only
About My Research
Center/Research Area Affiliations
- AMD Center of Excellence
- Mobility Enhancement and Vision Rehabilitation Center of Excellence
- Ocular Genomics Institute
- Ocular Regenerative Medicine Institute
- Berman-Gund Laboratory for the Study of Retinal Degenerations
Biography
Dr. Comander’s research interests include understanding the molecular basis of retinal degenerations, such as retinitis pigmentosa, and pursuing therapies for these disorders. He has published studies on the natural history of retinitis pigmentosa and other retinal disorders. Currently, he developing new techniques to speed characterization of potentially-disease causing DNA variants, testing gene therapy techniques in primates, and is an investigator and surgeon for a number of ongoing clinical trials for patients with inherited retinal disorders.
Education
1997: AB, Harvard College
2005: PhD., Experimental Pathology, Harvard Medical School
2006: MD, Harvard Medical School
Postgraduate Training
2007: Fellowship/Internship, Medicine, Brigham & Women's Hospital
2010: Residency, Ophthalmology, Harvard Medical School
2012: Clinical Fellowship, Vitreoretinal Surgery, Massachusetts Eye and Ear
Academic Appointments
2012-present Instructor in Ophthalmology, Harvard Medical School
Professional Memberships
1999-present: Member, Massachusetts Medical Society
1999-present: Member, American Association for the Advancement of Science
1991-1994, 2009-present: Member, Association for Research in Vision and Ophthalmology
2002-2006: Member, National Association for Vascular Biology
2007-present: Member, American Academy of Ophthalmology
Honors
1993: Finalist, Presidential Scholars
1997: John Harvard Scholarship
1998: Medical Scientist Training Program Scholarship for M.D./Ph.D. Program at Harvard Medical School
2005: Massachusetts Medical Society Information Technology Award
2009: Attendee, Heed Foundation Retreat for Academic Ophthalmology
2013: Research to Prevent Blindness Career Development Award
Publications powered by Harvard Catalyst Profiles
- Repair of Rhegmatogenous Retinal Detachment in Choroideremia Secondary to Posterior Extramacular Retinal Hole. Ophthalmic Surg Lasers Imaging Retina. 2024 Jan; 55(1):9-11.
- Classification and Growth Rate of Chorioretinal Atrophy after Voretigene Neparvovec-Rzyl for RPE65-Mediated Retinal Degeneration. Ophthalmol Retina. 2024 Jan; 8(1):42-48.
- Natural history of retinitis pigmentosa based on genotype, vitamin A/E supplementation, and an electroretinogram biomarker. JCI Insight. 2023 08 08; 8(15).
- Structure-based network analysis predicts mutations associated with inherited retinal disease. medRxiv. 2023 Jul 06.
- Perspectives of Rare Disease Experts on Newborn Genome Sequencing. JAMA Netw Open. 2023 05 01; 6(5):e2312231.
- Intravitreal Delivery of rAAV2tYF-CB-hRS1 Vector for Gene Augmentation Therapy in Patients with X-Linked Retinoschisis: 1-Year Clinical Results. Ophthalmol Retina. 2022 Dec; 6(12):1130-1144.
- Adeno-Associated Virus Serotype 2-hCHM Subretinal Delivery to the Macula in Choroideremia: Two-Year Interim Results of an Ongoing Phase I/II Gene Therapy Trial. Ophthalmology. 2022 10; 129(10):1177-1191.
- Adeno-associated Viral Vectors in the Retina: Delivering Gene Therapy to the Right Destination. Int Ophthalmol Clin. 2022 Apr 01; 62(2):215-229.
- Repair of Rhegmatogenous Retinal Detachment in Choroideremia Secondary to Posterior Extramacular Retinal Hole. Ophthalmic Surg Lasers Imaging Retina. 2022 04; 53(4):182-184.
- Novel RCBTB1 variants causing later-onset non-syndromic retinal dystrophy with macular chorioretinal atrophy. Ophthalmic Genet. 2022 06; 43(3):332-339.
- Beyond Sector Retinitis Pigmentosa: Expanding the Phenotype and Natural History of the Rhodopsin Gene Codon 106 Mutation (Gly-to-Arg) in Autosomal Dominant Retinitis Pigmentosa. Genes (Basel). 2021 11 23; 12(12).
- Moving Towards PDE6A Gene Supplementation Therapy. JAMA Ophthalmol. 2020 12 01; 138(12):1251-1252.
- Peripheral Leakage on Ultra-Widefield Fluorescein Angiography in Patients With Inherited Retinal Degeneration. J Vitreoretin Dis. 2021 Mar-Apr; 5(2):147-156.
- Biallelic RP1-associated retinal dystrophies: Expanding the mutational and clinical spectrum. Mol Vis. 2020; 26:423-433.
- Copy-number variation contributes 9% of pathogenicity in the inherited retinal degenerations. Genet Med. 2020 06; 22(6):1079-1087.
- Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses. Nat Biomed Eng. 2020 01; 4(1):97-110.
- Characterizing variants of unknown significance in rhodopsin: A functional genomics approach. Hum Mutat. 2019 08; 40(8):1127-1144.
- Current Stem-Cell Approaches for the Treatment of Inherited Retinal Degenerations. Semin Ophthalmol. 2019; 34(4):287-292.
- Predictive value of genetic testing for inherited retinal diseases in patients with suspected atypical autoimmune retinopathy. Am J Ophthalmol Case Rep. 2019 Sep; 15:100461.
- Characterization of Epiretinal Proliferation in Full-Thickness Macular Holes and Effects on Surgical Outcomes. Ophthalmol Retina. 2019 08; 3(8):694-702.
- High Reliability of Cone Cell Measurements With Adaptive Optics Scanning Laser Ophthalmoscopy in a Simulated Real-Life Clinical Setting. Ophthalmic Surg Lasers Imaging Retina. 2018 04 01; 49(4):228-235.
- Synthetic Adeno-Associated Viral Vector Efficiently Targets Mouse and Nonhuman Primate Retina In Vivo. Hum Gene Ther. 2018 07; 29(7):771-784.
- The importance of genetic testing as demonstrated by two cases of CACNA1F-associated retinal generation misdiagnosed as LCA. Mol Vis. 2017; 23:695-706.
- The Genetic Basis of Pericentral Retinitis Pigmentosa-A Form of Mild Retinitis Pigmentosa. Genes (Basel). 2017 Oct 05; 8(10).
- Reply. Am J Ophthalmol. 2017 11; 183:166-167.
- Retinal pigmentary changes in chronic uveitis mimicking retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol. 2017 Sep; 255(9):1801-1810.
- Outcomes in Autoimmune Retinopathy Patients Treated With Rituximab. Am J Ophthalmol. 2017 Aug; 180:124-132.
- Management of Cystoid Macular Edema in Retinitis Pigmentosa. Semin Ophthalmol. 2017; 32(1):43-51.
- NOD2 genetic variants and sarcoidosis-associated uveitis. Am J Ophthalmol Case Rep. 2016 Oct; 3:39-42.
- Course of Ocular Function in PRPF31 Retinitis Pigmentosa. Semin Ophthalmol. 2016; 31(1-2):49-52.
- Efficient In Silico Identification of a Common Insertion in the MAK Gene which Causes Retinitis Pigmentosa. PLoS One. 2015; 10(11):e0142614.
- Visual Function in Carriers of X-Linked Retinitis Pigmentosa. Ophthalmology. 2015 Sep; 122(9):1899-906.
- Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. PLoS One. 2011; 6(9):e24245.
- Diagnostic testing and disease monitoring in birdshot chorioretinopathy. Semin Ophthalmol. 2011 Jul-Sep; 26(4-5):329-36.
- High-resolution optical coherence tomography findings in solar maculopathy and the differential diagnosis of outer retinal holes. Am J Ophthalmol. 2011 Sep; 152(3):413-419.e6.
- Accommodating intraocular lenses: theory and practice. Int Ophthalmol Clin. 2010; 50(1):107-17.
- Improving the statistical detection of regulated genes from microarray data using intensity-based variance estimation. BMC Genomics. 2004 Feb 27; 5(1):17.
- Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem. 2002 Nov 15; 277(46):44147-54.
- Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis? Ann N Y Acad Sci. 2001 Dec; 947:1-6.
- Argus--a new database system for Web-based analysis of multiple microarray data sets. Genome Res. 2001 Sep; 11(9):1603-10.
- Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4478-85.
- Computational comparison of two draft sequences of the human genome. Nature. 2001 Feb 15; 409(6822):856-9.
- Quantification of holmium: YAG and thulium: YAG laser-induced scleral shrinkage for buckling procedures. Ophthalmic Surg Lasers. 1998 May; 29(5):410-21.
- Interstitial laser hyperthermia model development for minimally invasive therapy of breast carcinoma. J Am Coll Surg. 1998 Mar; 186(3):284-92.
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