Center/Research Area Affiliations
Dr. Cho focuses on why neurons in the central nervous system (CNS) cannot regrow in adult mammals. He discovered that the CNS environment expresses growth inhibitory molecules that block axonal regeneration in vivo and in vitro. He then demonstrated that the maturation of astrocytes correlates to the onset of growth inhibitory mechanism in the CNS. He was the first to report that a high proportion of retinal ganglion cell axons regenerate after injury over a long distance into brain targets. In addition to CNS regeneration, Dr. Cho also investigates the pathogenesis of experimental glaucoma and the potential application of retinal stem cells to treat retinal degenerative diseases.
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