About My Research
Dr. Jeffrey Tao Cheng’s primary research interests are in the area of structure and function relations of normal and pathological ears, as well as damage of the ear and how to repair it for hearing restoration.
Dr. Cheng’s laboratory uses newly developed laser imaging techniques, such as holography, optical coherence tomography, and laser doppler vibrometry, to measure sound-induced vibrations of the middle ear, including the tympanic membrane (eardrum) and the middle ear ossicles, with a nanometer-scale resolution. These measurements greatly improve our knowledge of how the middle ear responds to sound and conducts sound energy into the inner ear for hearing.
Measurements on pathological ears contribute to new views on how to diagnose and reconstruct diseased middle ears. For example, a detailed analysis of full-field tympanic membrane transient motions recorded by high-speed holography (>50,000 frames per second) on pathological ears could benefit diagnoses of middle-ear diseases and help plan for preoperative treatment as well as post-treatment evaluation.
Dr. Cheng also collaborates with physicians and optical and material science experts to develop and test multimodal otoendoscopy devices for non-invasive diagnosis and treatment of middle and inner ear diseases. He is also working to develop new 3-D printed tissue-engineered materials to repair damaged ears.
- Inaccuracies of deterministic finite-element models of human middle ear revealed by stochastic modelling. Sci Rep. 2023 05 05; 13(1):7329.
- Numerical model characterization of the sound transmission mechanism in the tympanic membrane from a high-speed digital holographic experiment in transient regime. Acta Biomater. 2023 03 15; 159:63-73.
- Characterization and Clinical Use of Bone Conduction Transducers at Extended High Frequencies. Hear Res. 2023 03 01; 429:108688.
- Methods for the calibration of bone conduction transducers at frequencies from 5 to 20 kHz. J Acoust Soc Am. 2022 05; 151(5):2945.
- The onset of nonlinear growth of middle-ear responses to high intensity sounds. Hear Res. 2021 06; 405:108242.
- Material characterization of thin planar structures using full-field harmonic vibration response measured with stroboscopic holography. Int J Mech Sci. 2021 May 15; 198.
- Multiple angle digital holography for the shape measurement of the unpainted tympanic membrane. Opt Express. 2020 Aug 17; 28(17):24614-24628.
- Optical coherence tomographic measurements of the sound-induced motion of the ossicular chain in chinchillas: Additional modes of ossicular motion enhance the mechanical response of the chinchilla middle ear at higher frequencies. Hear Res. 2020 10; 396:108056.
- Do high-frequency air-bone gaps persist after ossiculoplasty? Laryngoscope Investig Otolaryngol. 2020 Aug; 5(4):734-742.
- High-Frequency Conductive Hearing following Total Drum Replacement Tympanoplasty. Otolaryngol Head Neck Surg. 2020 Jun; 162(6):914-921.
- Limitations of present models of blast-induced sound power conduction through the external and middle ear. J Acoust Soc Am. 2019 11; 146(5):3978.
- High-Speed Holographic Shape and Full-Field Displacement Measurements of the Tympanic Membrane in Normal and Experimentally Simulated Pathological Ears. Appl Sci (Basel). 2019 Jul 02; 9(14).
- Sound pressure distribution within human ear canals: II. Reverse mechanical stimulation. J Acoust Soc Am. 2019 03; 145(3):1569.
- Tympanic membrane surface motions in forward and reverse middle ear transmissions. J Acoust Soc Am. 2019 01; 145(1):272.
- Blunting of the Anterior Tympanomeatal Angle Following Tympanoplasty. Otol Neurotol. 2018 12; 39(10):e1179-e1181.
- Mapping the phase and amplitude of ossicular chain motion using sound-synchronous optical coherence vibrography. Biomed Opt Express. 2018 Nov 01; 9(11):5489-5502.
- Combined high-speed holographic shape and full-field displacement measurements of tympanic membrane. J Biomed Opt. 2018 09; 24(3):1-12.
- Otopathologic evaluation of temporalis fascia grafts following successful tympanoplasty in humans. Laryngoscope. 2018 10; 128(10):E351-E358.
- Design, fabrication, and in vitro testing of novel three-dimensionally printed tympanic membrane grafts. Hear Res. 2016 10; 340:191-203.
- Response of the human tympanic membrane to transient acoustic and mechanical stimuli: Preliminary results. Hear Res. 2016 10; 340:15-24.
- Investigation of middle ear anatomy and function with combined video otoscopy-phase sensitive OCT. Biomed Opt Express. 2016 Feb 01; 7(2):238-50.
- In-plane and out-of-plane motions of the human tympanic membrane. J Acoust Soc Am. 2016 Jan; 139(1):104-17.
- Three-dimensional vibrometry of the human eardrum with stroboscopic lensless digital holography. J Biomed Opt. 2015 May; 20(5):051028.
- The Effect of Ear Canal Orientation on Tympanic Membrane Motion and the Sound Field Near the Tympanic Membrane. J Assoc Res Otolaryngol. 2015 Aug; 16(4):413-32.
- Optimization of a lensless digital holographic otoscope system for transient measurements of the human tympanic membrane. Exp Mech. 2015 Feb 01; 55(2):459-470.
- Sound pressure distribution within natural and artificial human ear canals: forward stimulation. J Acoust Soc Am. 2014 Dec; 136(6):3132.
- Full-field transient vibrometry of the human tympanic membrane by local phase correlation and high-speed holography. J Biomed Opt. 2014 Sep; 19(9):96001.
- Comparisons of the mechanics of partial and total ossicular replacement prostheses with cartilage in a cadaveric temporal bone preparation. Acta Otolaryngol. 2014 Aug; 134(8):776-84.
- Aligning digital holography images of tympanic membrane motion. J Acoust Soc Am. 2014 Apr; 135(4):2416.
- Viscoelastic properties of the human tympanic membrane studied with stroboscopic holography and finite element modeling. Hear Res. 2014 Jun; 312:69-80.
- Digital holographic measurements of shape and 3D sound-induced displacements of Tympanic Membrane. Opt Eng. 2013 Oct 01; 52(10):101916.
- Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles. Hear Res. 2013 Oct; 304:49-56.
- Wave motion on the surface of the human tympanic membrane: holographic measurement and modeling analysis. J Acoust Soc Am. 2013 Feb; 133(2):918-37.
- Assessing eardrum deformation by digital holography. SPIE Newsroom. 2013 Jan 09.
- Measurements of three-dimensional shape and sound-induced motion of the chinchilla tympanic membrane. Hear Res. 2013 Jul; 301:44-52.
- New data on the motion of the normal and reconstructed tympanic membrane. Otol Neurotol. 2011 Dec; 32(9):1559-67.
- Holographic otoscope for nanodisplacement measurements of surfaces under dynamic excitation. Scanning. 2011 Sep-Oct; 33(5):342-52.
- Motion of the surface of the human tympanic membrane measured with stroboscopic holography. Hear Res. 2010 May; 263(1-2):66-77.
- Middle ear mechanics of cartilage tympanoplasty evaluated by laser holography and vibrometry. Otol Neurotol. 2009 Dec; 30(8):1209-14.
- Motion of the tympanic membrane after cartilage tympanoplasty determined by stroboscopic holography. Hear Res. 2010 May; 263(1-2):78-84.
- Finite element modeling of sound transmission with perforations of tympanic membrane. J Acoust Soc Am. 2009 Jul; 126(1):243-53.
- Optoelectronic holographic otoscope for measurement of nano-displacements in tympanic membranes. J Biomed Opt. 2009 May-Jun; 14(3):034023.
- Computer-assisted time-averaged holograms of the motion of the surface of the mammalian tympanic membrane with sound stimuli of 0.4-25 kHz. Hear Res. 2009 Jul; 253(1-2):83-96.
- Mechanical properties of stapedial tendon in human middle ear. J Biomech Eng. 2007 Dec; 129(6):913-18.
- Mechanical properties of anterior malleolar ligament from experimental measurement and material modeling analysis. Biomech Model Mechanobiol. 2008 Oct; 7(5):387-94.
- Finite-element analysis of middle-ear pressure effects on static and dynamic behavior of human ear. J Acoust Soc Am. 2007 Aug; 122(2):906-17.
- Experimental measurement and modeling analysis on mechanical properties of tensor tympani tendon. Med Eng Phys. 2008 Apr; 30(3):358-66.
- Fixation and detachment of superior and anterior malleolar ligaments in human middle ear: experiment and modeling. Hear Res. 2007 Aug; 230(1-2):24-33.
- Viscoelastic properties of human tympanic membrane. Ann Biomed Eng. 2007 Feb; 35(2):305-14.
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