Research Area Affiliations
Dr. Bleier’s research focuses on the role of sinonasal mucosal barrier function in the pathogenesis of chronic rhinosinusitis. Using a combination of immunohistochemical and air-liquid interface primary epithelial culture techniques, his laboratory is working to determine how transmembrane epithelial proteins, such as the ATP-binding cassette(ABC) transporter P-glycoprotein, functions to promote the elaboration of Th1 and Th2 skewed cytokines in the setting of chronic inflammatory disease states (Figure).
An additional synergistic interest is studying mucosal permeability and epithelial responses to a variety of topical therapeutics and drug eluting polymers. Using both in vitro and animal models, Dr. Bleier is working to develop methods to bypass the blood-brain barrier using advanced endoscopic surgical techniques. He also studies the ability to couple these procedures with biocompatible materials to enhance the treatment of neurodegenerative disorders and local sinonasal disease.
If you wish to contribute to Dr. Benjamin Bleier's research, please contact Irene Hammer-Mclaughlin.
View a complete list of publications on pubmed.gov »