Mary E Aronow, M.D.


Research Summary

Research Summary

Dr. Aronow's research focuses on understanding the role of biomarkers in assessing response to therapy in uveal melanoma, the most common primary intraocular malignancy in adults. Specifically, she is investigating the role of plasma tumor DNA (ptDNA) in monitoring disease activity following treatment of these tumors. Ultimately, the goal is to develop highly targeted therapies for patients with uveal melanoma. As newer therapies become available, ptDNA has the potential to serve as a biomarker for assessing treatment efficacy. Macro-metastatic disease detected with CT or MRI imaging may take five or more years to develop. In contrast, ptDNA has the potential to serve as a marker of disease activity, thus allowing for detection of micro-metastases at an earlier time point and intervention with promising adjuvant therapies. 

Selected Publications

For a full publication list, please see her CV.

Singh AD, Medina CA, Singh N, Aronow ME, Biscotti CV, Triozzi PL. Fine-needle aspiration biopsy of uveal melanoma: outcomes and complications. Br J Ophthalmol. 2016 Apr;100(4):456-62.

Campochiaro PA, Hafiz G, Mir TA, Scott AW, Zimmer-Galler I, Shah SM, Wenick AS, Brady CJ, Han I, He L, Channa R, Poon D, Meyerle C, Aronow ME, Sodhi A, Handa JT, Kherani S, Han Y, Sophie R, Wang G, Qian J. Pro-permeability factors in diabetic macular edema; the diabetic macular edema treated with ozurdex trial. Am J Ophthalmol. 2016;168:13-23.

Aronow ME, Murray TG, Shields CL. Key Opinion Leaders: Diagnosing and managing choroidal nevi and melanoma. Retina Times. 2015;33(5):32-41.

Aronow ME, Shen D, Hochman J, Chan CC. Intraocular lymphoma models. Ocular Oncol Pathol. 2015;1:214-22.

Aronow ME. Ocular adnexal lymphoma: evidence-based treatment approach. Int Ophthalmol Clin. 2015;55(1):97-109.

View a complete list of publications on pubmed.gov>>


Biosketch

Education

1997: BS, with Honors and Distinction, Cornell University

2000: Postbaccalaureate Premedical Program, Bryn Mawr College

2006: MD, cum laude, Yale University School of Medicine

Postgraduate Training

2010: Residency, Ophthalmology, Cole Eye Institute

2011: Fellowship, Ophthalmic Oncology, Cole Eye Institute

2014: Fellowship, Medical Retina, National Eye Institute, National Institutes of Health

Honors

2003: Yale University School of Medicine Intensive Pedagogical Research Program      

2003: Orthopedic Research and Education Foundation Grant Award Recipient

2006: Alpha Omega Alpha Honor Medical Society, Yale University Chapter      

2011: Best Fellow Paper/Presentation, Cole Eye Institute, Residents Day, Cleveland Clinic