Joseph F. Arboleda-Velasquez, M.D., Ph.D.

Research Summary

Center/Research Area Affiliations

Research Summary

Dr. Arboleda-Velasquez is interested in the study of the cell signaling mechanisms controlling the integrity of the vasculature in a diabetic environment. He uses novel technologies to study cell-cell and protein-protein interactions using imaging methods and enzymes to explore the cell signaling circuitry underlying diabetic microangiopathy. In addition, he is investigating novel mechanisms contributing to proliferative diabetic retinopathy using patient-derived cell cultures and next generation sequencing approaches. This research may lead to therapeutic approaches for diabetic retinopathy, which stands as the most prevalent cause of blindness in working adults.

Selected Publications

From pathobiology to the targeting of pericytes for the treatment of diabetic retinopathy. Arboleda-Velasquez JF, Valdez CN, Marko CK, D'Amore PA. Curr Diab Rep. 2015 Feb;15(2):573.

Retinal microangiopathy in a mouse model of inducible mural cell loss. Valdez CN, Arboleda-Velasquez JF, Amarnani DS, Kim LA, D'Amore PA. Am J Pathol. 2014 Oct;184(10):2618-26

Notch signaling functions in retinal pericyte survival. Arboleda-Velasquez JF, Primo V, Graham M, James A, Manent J, D'Amore PA. Invest Ophthalmol Vis Sci. 2014 Jul 11;55(8):5191-9.

Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Proc Natl Acad Sci U S A. 2011 May 24;108(21):E128-35.

Case records of the Massachusetts General Hospital. Case 12-2009. A 46-year-old man with migraine, aphasia, and hemiparesis and similarly affected family members. Brass SD, Smith EE, Arboleda-Velasquez JF, Copen WA, Frosch MP. N Engl J Med. 2009 Apr 16;360(16):1656-65.

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M.D. University of Antioquia, Medellin, Colombia

Ph.D. Harvard Medical School

Postgraduate Training

2010 - 2011
Research Fellowship, Schepens Eye Research Institute, Harvard Medical School

Academic Appointments

2012 - present
Instructor in Ophthalmology, Harvard Medical School