Daniel M. Merfeld, Ph.D.
Professor of Otology and Laryngology, Harvard Medical School
Director, Jenks Vestibular Physiology Laboratory,
Massachusetts Eye and Ear Infirmary
An accomplished neuroengineer/psychophysicist, Dr. Merfeld is the founding Director of the Jenks Vestibular Physiology Laboratory. Performing basic and translational vestibular research, Dr. Merfeld has shown that tilt and translation perception result from multisensory signal convergence via internal models. Much of his early research focused on understanding how the brain processes ambiguous sensory information with a specific focus on how signals from the otolith organs are interpreted and processed by the nervous system. His research – both modeling and experimental – has shown that the nervous system uses rotational signals from the canals to help keep track of the relative orientation of gravity via internal models. More recently, his research showed for the first time that vestibular “perception” and “action” can use qualitatively different neural mechanisms. Recent research builds on these earlier findings and focuses on the measurement of thresholds, which is one way to assay vestibular “noise” so that we can learn how vestibular information is processed in the presence of noise. His most recent basic research focuses on understanding how the brain processes information in the presence of noise. As translational research, Dr. Merfeld and his colleagues developed vestibular implants and demonstrated feasibility of this new treatment for vestibular loss. Massachusetts Eye and Ear Infirmary has licensed the patents to MedEl who is working to bring this treatment option to the clinic. Current translational efforts focus on developing vestibular thresholds as a technique to help diagnose the large number of patients who report perceptual symptoms that go undiagnosed using traditional clinical diagnostic techniques.
Please also see Dr. Merfeld’s Harvard Catalyst profile.
Humans use an internal model to estimate gravity and linear acceleration. Merfeld DM, Zupan L, Peterka RJ (1999). Nature 398:615:618
Frequency dependence of vestibulo-ocular reflex thresholds. Haburcakova, C, Lewis, RF, Merfeld DM (2012) Journal of Neurophysiology 107:973-983.
A distributed, dynamic, parallel computational model: the role of noise in velocity storage. Karmali, F, Merfeld DM (2012) Journal of neurophysiology, 108(2):390-405.
Vestibular labyrinth contributions to human whole-body motion discrimination. Valko, Y, Priesol AJ, Lewis R, Merfeld DM (2012) Journal of Neuroscience 32(39):13537-42.
Electrical stimulation of semicircular canal afferents affects the perception of head orientation. Lewis RF, Haburcakova C, Gong W, Lee D, Merfeld DM (2013) The Journal of Neuroscience 33(22):9530-5.