Michael J. McKenna, M.D.
Professor of Otology and Laryngology, Harvard Medical School
Otosclerosis is a disease of the otic capsule that is among the most common causes of acquired hearing loss. During the last 15 years, our laboratory has focused on elucidating the molecular pathology of otosclerosis with the long-term goal of developing better forms of therapy. These studies have brought us to the point where we are ready to consider and develop new and innovative treatment strategies. We have identified a promising pharmacological treatment, have begun to develop and test a drug formulation for use in humans, and have developed an animal model with which to test this therapy.
Our group, in conjunction with Draper Laboratories, is also working on the development of a versatile intracochlear drug delivery system for ultimate use in humans.
1. McKenna MJ, Mills BG, Galey FR, Linthicum FH Jr. Filamentous structures morphologically similar to viral nucleocapsids in otosclerotic lesions in two patients. Am J Otol 1986;7(1):25-8.
2. McKenna MJ, Kristiansen AG, Haines J. Polymerase chain reaction amplification of a measles virus sequence from human temporal bone sections with active otosclerosis. Am J Otol 1996;17:827-30.
3. McKenna MJ, Kristiansen AG, Bartley ML, Rogus JJ, Haines JL. Association of COL1A1 and otosclerosis: evidence for a shared etiology with mild osteogenesis imperfecta. Am J Otol 1998;19:604-10.
4. McKenna MJ, Kristiansen AG, Körkkö J. Sequence analysis of COL1A1 and COL1A2 genes in clinical otosclerosis: no evidence for mutations in the coding regions of the genes. Otorhinolaryngol Nova 2003;11:267-70.
5. Zehnder AF, Kristiansen AG, Adams JC, Merchant SN, McKenna MJ. Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule. Laryngoscope 2005;115(1):172-177.
6. Zehnder AF, Kristiansen AG, Adams JC, Kujawa SG, Merchant SN, McKenna MJ. Osteoprotegerin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss. Laryngoscope 2006;116:201-6.