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Otopathology Research

Dr. Merchant is the Director of the Otopathology Laboratory whose long term goal is to provide insight into the causes, pathogenesis, treatment and prevention of otologic disease through the study of temporal bones obtained from subjects with well-documented ear disease. Temporal bones are studied by a variety of techniques including traditional light microscopy, immunohistochemistry and computer-aided morphometry. Selected cases are also studied by genomic and proteomic techniques. The application of genomic and proteomic assays to temporal bone research offers great potential for realizing the promise of molecular otopathology. A computerized data base is used to store, analyze, and retrieve all clinical and pathologic data. Our temporal bone collection also serves as a resource for the training of residents and researchers, and particularly for the training of academic otologists through the mechanism of research fellowships.

Learn more about the Otopathology Laboratory at http://otopathologynetwork.org/about/labs/otopathology/

The Otopathology Laboratory is the headquarters of the Otopathology Research Collaboration Network established by the NIH. Learn more about the Network at http://otopathologynetwork.org/

Selected Publications

1. Merchant SN, Durand ML, Adams JC. Sudden deafness- is it viral? ORL 2008;70:52-62.

2. Fayez B, Merchant SN. Histopathology of ossicular grafts and implants in chronic otitis media. Ann Otol Rhinol Laryngol 2007; 116:181-191.

3. Bahmad F, Merchant SN, Nadol JB Jr., Tranebjærg L. Otopathology in Mohr-Tranebjærg syndrome. Laryngoscope 2007; 117:1202-1208.

4. Wang H, Merchant SN, Sorensen MS. A Downloadable 3-D Virtual Model of the Visible Ear. ORL 2006;69:63-67.

5. Griffith AJ, Yang Y, Pryor SP, Park HJ, Jabs EW, Nadol JB, Russell LJ, Wasserman DI, Richard G, Adams JC, Merchant SN. Cochleosaccular dysplasia associated with a Connexin 26 mutation in KID syndrome. Laryngoscope 2006; 116:1404-1408.