Ahmad R. Sedaghat, MD, PhD

Undergraduate School: Columbia University, Biomedical engineering
Medical School: The Johns Hopkins School of Medicine
Graduate School: The Johns Hopkins School of Medicine, Immunology
Research Interests: Allergic rhinitis and chronic rhinosinusitis
Website: www.ahmadsedaghat.com

Publications:

  1. Connexin 32 and 43 mutations: Do they play a role in chronic rhinosinusitis? Sedaghat AR, Cunningham MJ, Busaba NY. Am J Otolaryngol. 2013 Oct 9. pii: S0196-0709(13)00199-3.
     
  2. Preapproval of sinus computed tomography for otolaryngologic evaluation of chronic rhinosinusitis does not save health care costs. Sedaghat AR, Gray ST, Kieff DA. Laryngoscope. 2013 Jun 22.
     
  3. Nasal obstruction and anosmia. Chambers KJ, Sedaghat AR, Roberts DS, Caradonna DS. JAMA Otolaryngol Head Neck Surg. 2013 Aug 1;139(8):851-2.
     
  4. Sinonasal Variants and Asthma are Associated with Faster Development of Chronic Rhinosinusitis in Patients with Allergic Rhinitis. A.R. Sedaghat, S.T. Gray, K. Chambers, C.O. Wilke and D.S. Caradonna. International Forum of Allergy and Rhinology. In review.
     
  5. Clinical Assessment is an Accurate Predictor of Which Patients Will Need Septoplasty. A.R. Sedaghat, N.Y. Busaba, M.J. Cunningham and D.A. Kieff. 2012. Laryngoscope. In press.
     
  6. Radiology Quiz Case: Malleus Fixation. D. Ginat, A.R. Sedaghat, C. Robson and K.R. Whittemore. 2012. Archives of Otolaryngology-Head and Neck Surgery. 138(8):775-6
     
  7. Radiographic Density Profiles Link Frontal and Anterior Ethmoid Sinuses Behavior in Chronic Rhinosinusitis. A.R. Sedaghat and N. Bhattacharyya. 2012. International Forum of Allergy and Rhinology.
     
  8. Risk Factors For Development of Chronic Rhinosinusitis In Patients with Allergic Rhinitis. A.R. Sedaghat, S.T. Gray, C.O. Wilke and D.S. Caradonna. 2012. International Forum of Allergy and Rhinology. 2(5):370-5.
     
  9. Chronic Rhinosinusitis Symptoms and Computed Tomography Staging: Improved Correlation by Incorporating Radiographic Density. A.R. Sedaghat and N. Bhattacharyya. 2012. International Forum of Allergy and Rhinology. 2(5):386-91.
     
  10. A Case-Control Comparison of Lingual Tonsillar Hypertrophy in Children with and without Down Syndrome. A.R. Sedaghat, R. Flax-Goldenberg, R. Gaylor and S.L. Ishman. 2012. Laryngoscope. 122(5): 1165-9.
     
  11. Does balloon catheter sinuplasty have a role in the surgical management of pediatric sinus disease? A.R. Sedaghat and M.J. Cunningham. 2011. Laryngoscope. 121(10):2053-4.
     
  12. A Multiple Equilibrium Model Provides a Theoretical Basis for Understanding Does-response Relationships of Antiretroviral Drugs. L. Shen, S.A. Rabi, A.R. Sedaghat, L. Shan, J. Lai, S. Xing and R.F. Siliciano. 2011. Sci Transl Med. 3(91):91ra63; 1-10.
     
  13. Kinetics of the Viral Cycle Influence Pharmacodynamics of Antiretroviral Therapy. A.R. Sedaghat and C.O. Wilke. 2011. Biology Direct. 6(1):42; 1-32.
     
  14. Characterization Of Obstructive Sleep Apnea Before And After Tongue Lip Adhesion In Children With Micrognathia. A.R. Sedaghat, I.C. Anderson, B.M. McGinley, M.I. Rossberg, R.J. Redett, and S.L. Ishman. 2011. Cleft Palate and Craniofacial Journal.
     
  15. Clinical Problem Solving Radiology Quiz Case: Pediatric Base of Tongue Thyroglossal Duct Cyst. A.R. Sedaghat, T.Q. Gallagher, P.M. Sadow, M.E. Cunnane and M.J. Cunningham. 2011. Archives of Otolaryngology-Head and Neck Surgery. 137(9):955
     
  16. Dynamic Constraints on the Second Phase Compartment of HIV-infected Cells. A. Spivak, A. Rabi, M.A. McMahon, L. Shan, A.R. Sedaghat, C.O. Wilke and R.F. Siliciano. 2010. AIDS Res Hum Retroviruses. 27(7):759-61.
     
  17. Prevalence and Severity of Obstructive Sleep Apnea and Snoring in Infants with Pierre Robin Sequence. I.C. Anderson, A.R. Sedaghat, B. McGinley, R. Redett, E. Boss and S. Ishman. 2010. Cleft Palate Craniofacial Journal. 48(5):614-8.
     
  18. T Cell Dynamics and The Response to HAART in a Cohort of HIV-1 Infected Elite Suppressors. A.R. Sedaghat, D.A. Rastegar, K.A. O'Connell, J.B. Dinoso, C.O. Wilke, and J.N. Blankson. 2009. Clin. Infect. Diseases. 49(11) 1763-6.
     
  19. Analysis of HIV-1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy. T.P. Brennan, J.O. Woods, A.R. Sedaghat, R.F. Siliciano, and C.O. Wilke. 2009. J. Virol. 83(17):8470-81.
     
  20. Evidence for minimal prognostic significance of HPV status in oropharyngeal squamous cell carcinomas. A.R. Sedaghat, Z. Zhang, S. Begum, W.H. Westra, S. Palermo, S. Best, K.M. Ulmer, M. Levine, E. Zinreich, B.P. Messing, D. Gold, J. Kowalski, R.M. Hirata, J.R. Saunders, and S.I. Pai. 2009. Laryngoscope. 119(8):1542-9.
     
  21. Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir. A.R. Sedaghat, R.F. Siliciano, and C.O. Wilke. 2009. Antiviral Therapy. 14(2): 263-271.
     
  22. Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs. L. Shen, S. Peterson, A.R. Sedaghat, M.A. McMahon, M. Callender, H. Zhang, Y. Zhou, E. Pitt, K.S. Anderson, E.P. Acosta, and R.F. Siliciano. 2008. Nat. Med. 14: 762-766.
     
  23. Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle. A.R. Sedaghat, J.B. Dinoso, L. Shen, C.O. Wilke, and R.F. Siliciano. 2008. Proc. Natl. Acad. Sci. U. S. A 105:4832-483.
     
  24. Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART. A.R. Sedaghat, R.F. Siliciano, and C.O. Wilke. 2008. BMC. Infect. Dis. 8:2.
     
  25. Chronic CD4+ T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics. A.R. Sedaghat, J. German, T.M. Teslovich, J. Cofrancesco, Jr., C.C. Jie, C.C. Talbot, Jr., and R.F. Siliciano. 2008. J. Virol. 82:1870-1883.
     
  26. Severe depletion of CD4+ CD25+ regulatory T cells from the intestinal lamina propria but not peripheral blood or lymph nodes during acute simian immunodeficiency virus infection. A.J. Chase, A.R. Sedaghat, J.R. German, L. Gama, M.C. Zink, J.E. Clements, and R.F. Siliciano. 2007. J. Virol. 81:12748-12757.
     
  27. Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART. A.R. Sedaghat., J.D. Siliciano, T.P. Brennan, C.O. Wilke, and R.F. Siliciano. 2007. PLoS. Pathog. 3:e122.
     
  28. Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J.R. Bailey*, A.R. Sedaghat*, T. Kieffer*, T. Brennan, P.K. Lee, M. Wind-Rotolo, C.M. Haggerty, A.R. Kamireddi, Y. Liu, J. Lee, D. Persaud, J.E. Gallant, J. Cofrancesco, Jr., T.C. Quinn, C.O. Wilke, S.C. Ray, J.D. Siliciano, R.E. Nettles, and R.F. Siliciano. 2006. J. Virol. 80:6441-6457.
     
  29. Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes. Y. Han, K. Lassen, D. Monie, A.R. Sedaghat, S. Shimoji, X. Liu, T.C. Pierson, J.B. Margolick, R.F. Siliciano, and J.D. Siliciano. 2004. J. Virol. 78:6122-6133.
     
  30. A mathematical model of metabolic insulin signaling pathways. A.R. Sedaghat, A. Sherman, and M.J. Quon. 2002. Am. J. Physiol Endocrinol. Metab 283:E1084-E1101