Dr. Merabet is an optometrist-scientist and is active in clinical research relating to individuals' adaptations to blindness. He also serves on the Board of Directors and Trustees of the Carroll Center for the Blind and the National Braille Press.

As director of the Laboratory for Visual Neuroplasticity, Dr. Merabet's main research interests include the development of assistive technology for the blind and understanding how the brain adapts to the loss of sight (both from ocular and brain-related causes). Much of this work is done in local collaboration with the Carroll Center and Perkins School for the Blind, Boston Children's Hospital, as well as internationally with the University of Chile and the University of Milan.