Clinical Interests

Ocular surface and corneal infections, ocular surface tumors, corneal transplantation and keratoprosthesis for the hopelessly corneal blind

Research Interests

Current Research: Our laboratory investigates the role of keratocytes, the resident cells of the eye’s corneal stroma, in the chemokine-driven innate immune responses to viral infection of the cornea. Specifically, we study signal transduction events in response to infection with adenoviruses in cultured human keratocytes and living murine models, at the nucleic acid, protein, and cellular levels, and how those signaling events influence the expression of pro-inflammatory mediators. The mechanisms uncovered in this research represent fundamental and highly conserved means by which tissue stromal cells respond to insult whether due to infection or trauma. Additionally, we have sequenced the genomes of those adenoviruses most commonly associated with the most severe forms of viral eye infection, and discovered a novel gene that may confer corneal tropism. Our long-term goal is to develop new information-based therapies for ocular surface and corneal inflammation due to viral infections and other insults.

Selected Publications

Please click here to download the biosketch. See his CV. See also below.

Xiao J, Natarajan K, Rajala MS, Astley RA, Ramadan RT, Chodosh J, Vitronectin: a possible determinant of adenovirus type 19 tropism for human corneal epithelium. Am J Ophthalmology 2005;140:363-369.

Xiao J, Chodosh J. JNK regulates MCP-1 expression by adenovirus type 19 infected human corneal fibroblasts. Invest Ophthalmol Vis Sci 2005;46:3777-3782.

Rajala MS, Rajala RVS, Astley RA, Butt AL, Chodosh J. Corneal cell survival in adenovirus type-19 infection requires phosphoinositide-3-kinase/Akt activation. J Virol 2005;79:12322-12341.

Butt AL, Chodosh J. Adenoviral keratoconjunctivitis in a tertiary care eye clinic. Cornea 2006;25:199-202.

Chodosh J. Human adenovirus type 37 and the Balb/c mouse: progress towards a restricted adenovirus keratitis model. (American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc 2006;104:338-357.

Chintakuntlawar AV, Astley RA, Chodosh J. Adenovirus type 37 keratitis in the C57BL/6J mouse. Invest Ophthalmol Vis Sci 2007;48:781-788.

Guess S, Stone DU, Chodosh J. Therapy for herpes simplex virus ocular disease: a systematic review of the literature. Ocular Surf 2007;5:240-250.

Rajaiya J, Xiao J, Rajala RVS, Chodosh J. Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression. Virol J 2008;5:17. (doi:10.1186/1743-422X-5-17)

Robinson CM, Shariati F, Gillaspy AF, Dyer, DW, Chodosh J. Genomic and bioinformatics analysis of HAdV-37: new insights into corneal tropism. BMC Genomics. 2008;9:213.

Sturges A, Butt AL, Lai JE, Chodosh J. Topical interferon or surgical excision for the management of primary ocular surface squamous neoplasia. Ophthalmology 2008 (In Press).

Publications

A self-updating, representative list of Dr. Chodosh's research publications available on www.pubmed.gov can be found here.

Page updated 7/9/10