James Chodosh, M.D., MPH
|Associate Director, Cornea and Refractive Surgery Service|
|Specialty:||Cornea and External Diseases|
Massachusetts Eye and Ear
243 Charles Street
Boston, MA 02114
|Office Hours:||Monday and Friday mornings|
|Graduate School||University of Oklahoma, College of Public Health|
|Medical School||Baylor College of Medicine|
|Residency||Ophthalmology, Baylor College of Medicine|
|Fellowship||Corneal and External Diseases and Surgery, Bascom Palmer Eye Institute|
|Teaching Affiliation||David G. Cogan Professor of Ophthalmology in the Field of Cornea and External Disease, Harvard Medical School|
Ocular surface and corneal infections, ocular surface tumors, corneal transplantation and keratoprosthesis
Our laboratory investigates the role of keratocytes, the resident cells of the eye’s corneal stroma, in the chemokine-driven innate immune responses to viral infection of the cornea. Specifically, we study signal transduction events in response to infection with adenoviruses in cultured human keratocytes and living murine models, at the nucleic acid, protein, and cellular levels, and how those signaling events influence the expression of pro-inflammatory mediators. The mechanisms uncovered in this research represent fundamental and highly conserved means by which tissue stromal cells respond to insult whether due to infection or trauma.
Wang L, Jeong KJ, Chiang HH, Zurakowski D, Behlau I, Chodosh J, Dohlman CH, Langer R, Kohane DS. Hydroxyapatite for keratoprosthesis biointegration. Invest Ophthalmol Vis Sci. 2011 Sep; 52(10): 7392-9.