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James Chodosh, M.D., MPH

Photo of James Chodosh, M.D., MPH
Associate Director, Cornea and Refractive Surgery Service
Specialty: Cornea and External Diseases
Phone Number: 617-573-3938
Fax: 617-573-4324
Location: Massachusetts Eye and Ear
243 Charles Street
Boston, MA 02114
Office Hours: Monday and Friday mornings
Board Certification: Ophthalmology
College Hampshire College
Graduate School University of Oklahoma, College of Public Health
Medical School Baylor College of Medicine
Residency Ophthalmology, Baylor College of Medicine
Fellowship Corneal and External Diseases and Surgery, Bascom Palmer Eye Institute
Teaching Affiliation David G. Cogan Professor of Ophthalmology in the Field of Cornea and External Disease, Harvard Medical School
Biographical Profile:

Dr. Chodosh is the Associate Director of the Cornea and Refractive Surgery Service, Director of Boston Keratoprosthesis Clinical Programs, and Director of Education and Fellowship training for the Cornea Service.

Clinical Interests

Ocular surface and corneal infections, ocular surface tumors, corneal transplantation and keratoprosthesis

Research Interests

Our laboratory investigates the role of keratocytes, the resident cells of the eye’s corneal stroma, in the chemokine-driven innate immune responses to viral infection of the cornea. Specifically, we study signal transduction events in response to infection with adenoviruses in cultured human keratocytes and living murine models, at the nucleic acid, protein, and cellular levels, and how those signaling events influence the expression of pro-inflammatory mediators. The mechanisms uncovered in this research represent fundamental and highly conserved means by which tissue stromal cells respond to insult whether due to infection or trauma.

Additionally, we have sequenced the genomes of those adenoviruses most commonly associated with the most severe forms of viral eye infection, and discovered a novel gene that may confer corneal tropism. Our long-term goal is to develop new information-based therapies for ocular surface and corneal inflammation due to viral infections and other insults.


For a full publication list, please see his CV or biosketch. A representative list (2006 - 2012) is available through

Wang L, Jeong KJ, Chiang HH, Zurakowski D, Behlau I, Chodosh J, Dohlman CH, Langer R, Kohane DS. Hydroxyapatite for keratoprosthesis biointegration. Invest Ophthalmol Vis Sci. 2011 Sep; 52(10): 7392-9.

Robinson CM, Rajaiya J, Zhou X, Singh G, Dyer DW, Chodosh J. The E3 CR1-gamma gene in human adenoviruses associated with epidemic keratoconjunctivitis. Virus Res. 2011 Sep; 160 (1-2): 120-7.

Todani A, Ciolino JB, Ament JD, Colby KA, Pineda R, Belin MW, Aquavella JV, Chodosh J, Dohlman CH. Titanium back plate for a PMMA keratoprosthesis: clinical outcomes. Graefes Arch Clin Exp Ophthalmol. 2011 Oct; 249 (10): 1515-8.

Walsh MP, Seto J, Liu EB, Dehghan S, Hudson NR, Lukashev AN, Ivanova O, Chodosh J, Dyer DW, Jones MS, Seto D. Computational analysis of two species C human adenoviruses provides evidence of a novel virus. J Clin Microbiol. 2011 Oct; 49(10): 3482-90.

Dehghan S, Seto J, Hudson NR, Robinson CM, Jones MS, Dyer DW, Chodosh J, Seto D. Complete genome sequence of human adenovirus prototype 17. J Virol. 2011 Nov; 85(21): 11540-1.