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Janey Wiggs, M.D., Ph.D.

Photo of Janey Wiggs, M.D., Ph.D.
Associate Chief, Ophthalmology Clinical Research, and Associate Director, Ocular Genomics Institute
Specialty: Glaucoma
Phone Number: 617-573-3670
Fax: 617-573-6439
Location: Massachusetts Eye and Ear
243 Charles Street
Boston, MA 02114
Office Hours: Monday, 12:00pm - 5:00pm
Board Certification: Ophthalmology, Medical Genetics
Medical School Harvard Medical School
Residency Ophthalmology, Harvard Medical School Department of Ophthalmology Residency Training Program
Fellowship Glaucoma, Mass. Eye and Ear
Fellowship Medical Genetics, Tufts University School of Medicine
Teaching Affiliation Paul A. Chandler Associate Professor of Ophthalmology, Harvard Medical School
Biographical Profile:


Dr. Wiggs is the director of the CLIA-certified clinical diagnostic laboratory where patients are tested for mutations in genes that can cause early-onset glaucoma or primary optic neuropathy.

Clinical Interests

Complex and advanced glaucoma, inherited ocular disorders

Research Interests

The overall goal of Dr. Wigg's research program is to identify genetic factors that predispose to glaucoma. The identification of genes responsible for glaucoma will provide important information about the biology of the disease as well as lead to the development of gene-based diagnostic screening tests and inform novel therapies targeted to the molecular mechanisms contributing to disease pathogenesis.

Dr. Wiggs is currently investigating the genetic etiologies of several forms of glaucoma including adult onset primary open angle glaucoma (POAG), pseudoexfoliation glaucoma, early-onset glaucoma (congenital glaucoma, pigment dispersion syndrome and pigmentary glaucoma, glaucoma associated with Rieger syndrome and juvenile open angle glaucoma) as well as genes contributing to ocular quantitative traits that are risk factors for glaucoma development.

Publications

For a full publication list, please see her CV. A representative list (2006 - 2012) is available through www.pubmed.gov.

Fan BJ, Pasquale L, Grosskreutz CL, Rhee D, Chen T, DeAngelis MM, Kim I, del Bono E, Miller JW, Li T, Haines JL, Wiggs JL. DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a US clinic-based population with broad ethnic diversity. BMC Med Genet. 2008 Feb 6; 9: 5.

Crooks KR, Allingham RR, Qin X, Liu Y, Gibson JR, Santiago-Turla C, Larocque-Abramson KR, Del Bono E, Challa P, Herndon LW, Akafo S, Wiggs JL, Schmidt S, Hauser MA. Genomewide linkage scan for primary open angle glaucoma: influences of ancestry and age at diagnosis. PLoS One. 2011; 6(7): e21967.

Fan BJ, Wang DY, Pasquale LR, Haines JL, Wiggs JL. Genetic variants associated with optic nerve vertical cup-to-disc ratio are risk factors for primary open angle glaucoma in a US Caucasian population. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1788-92.

Fan BJ, Pasquale LR, Rhee D, Li T, Haines JL, Wiggs JL. LOXL1 promoter haplotypes are associated with exfoliation syndrome in a US Caucasian population. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5): 2372-8.

Wiggs JL, Hee Kang J, Yaspan BL, Mirel DB, Laurie C, Crenshaw A, Brodeur W, Gogarten S, Olson LM, Abdrabou W, Delbono E, Loomis S, Haines JL, Pasquale LR, for the GENEVA Consortium. Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA. Hum Mol Genet. 2011 Dec 1; 20(23): 4707-4713.