Janey Wiggs, M.D., Ph.D.
|Associate Chief, Ophthalmology Clinical Research, and Associate Director, Ocular Genomics Institute|
Massachusetts Eye and Ear
243 Charles Street
Boston, MA 02114
|Office Hours:||Monday, 12:00pm - 5:00pm|
|Board Certification:||Ophthalmology, Medical Genetics|
|Medical School||Harvard Medical School|
|Residency||Ophthalmology, Harvard Medical School Department of Ophthalmology Residency Training Program|
|Fellowship||Medical Genetics, Tufts University School of Medicine|
|Fellowship||Glaucoma, Mass. Eye and Ear|
|Teaching Affiliation||Paul A. Chandler Associate Professor of Ophthalmology, Harvard Medical School|
Complex and advanced glaucoma, inherited ocular disorders
The overall goal of Dr. Wigg's research program is to identify genetic factors that predispose to glaucoma. The identification of genes responsible for glaucoma will provide important information about the biology of the disease as well as lead to the development of gene-based diagnostic screening tests and inform novel therapies targeted to the molecular mechanisms contributing to disease pathogenesis.
Dr. Wiggs is currently investigating the genetic etiologies of several forms of glaucoma including adult onset primary open angle glaucoma (POAG), pseudoexfoliation glaucoma, early-onset glaucoma (congenital glaucoma, pigment dispersion syndrome and pigmentary glaucoma, glaucoma associated with Rieger syndrome and juvenile open angle glaucoma) as well as genes contributing to ocular quantitative traits that are risk factors for glaucoma development.
Fan BJ, Pasquale L, Grosskreutz CL, Rhee D, Chen T, DeAngelis MM, Kim I, del Bono E, Miller JW, Li T, Haines JL, Wiggs JL. DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a US clinic-based population with broad ethnic diversity. BMC Med Genet. 2008 Feb 6; 9: 5.