Reza Dana, M.D., M.Sc., MPH

Director, Cornea and Refractive Surgery Service and Associate Chief, Academic Programs

Specialties

Cornea and External Diseases

Immunology and Uveitis

Board Certification

  • Ophthalmology

Main Campus
243 Charles Street
Boston, MA 02114
Phone: 617-573-4331
Fax: 617-573-4300

Overview

Biography

Dr. Reza Dana is an internationally recognized expert in corneal disorders and ocular inflammation. He is a graduate of Johns Hopkins and Harvard Universities, who holds the Claes Dohlman Chair in Ophthalmology at Harvard Medical School. He is Director of the Cornea Service at the Massachusetts Eye and Ear, Senior Scientist at the Schepens Eye Research Institute/Mass Eye and Ear, and a member of the Harvard Medical School Graduate Program in Immunology (Committee on Immunology), and directs the Harvard-Vision Clinical Scientist Development Program. 

Dr. Dana has trained over 70 clinical fellows, and 105 postdoctoral fellows and students in his laboratory to date, the significant majority holding full-time academic positions in ophthalmology and vision research. He is recipient of the Harvard Medical School A. Clifford Barger Excellence in Mentoring Award.

Clinical Interests

High-Risk Transplantation, Stem cells, Graft-versus-Host Disease, Immune-Mediated Corneal Disorders, Infection, Autoimmunity

Research Interests

Corneal diseases and transplantation, dry eye syndrome, inflammatory corneal disorders, corneal stem cells, clinical trials

Publications

For a full publication list, please see his CV.

Liu Y, Hamrah P, Zhang Q, Taylor AW, Dana R. Draining lymph nodes of corneal transplant hosts exhibit evidence for donor MHC class II-positive dendritic cells derived from MHC class II-negative grafts. J Exp Medicine 2002; 195: 259-68.

Huq S, Liu Y, Benichou G, Dana R. Relevance of the direct pathway of sensitization in corneal transplantation is dictated by the graft bed microenvironment. J Immunol 2004: 173:4464-9.

Chen L, Hamrah L, Cursiefen C, Zhang Q, Pytowski B, Streilein JW, Dana R. Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) mediates induction of immunity to corneal transplants. Nature Med 2004; 10: 813-815.

Cursiefen C, Chen L, Saint-Geniez M, Hamrah P, Jin Y, Rashid S, Pytowski B, Persaud K, Wu Y, Streilein JW, Dana R. Nonvascular VEGFR-3 expression by corneal epithelium maintains avascularity and vision. Proc Nat Acad Sci USA 2006: 103:11405-10.

Shen L, Jin Y, Freeman GJ, Sharpe AH, Dana R. The function of donor versus recipient PD-L1 in corneal allograft survival. J Immunology 2007; 179: 3672-9.

Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunology 2009; 182: 1247-52.

Chauhan SK, Saban DR, Lee HK, Dana R. Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. J Immunology 2009; 182: 148-153. PMC2610348.

Saban DR, Chauhan SK, Masli S, Dana R. Thrombospondin-1 derived from antigen-presenting cells regulates their capacity for allosensitization. J Immunol 2010; 185: 4691-4697. PMC3090006.

Lee HK, Chauhan SK, Kay ED, Dana R. Flt-1 regulates cell migration via a protein tyrosine kinase-7-dependant pathway. Blood 2011;117:5762-71.

Jin Y, Chauhan SK, Annan JE, Sage PT, Sharpe AH, Dana R. A novel function for programmed death ligand-1 regulation of angiogenesis. Am J Pathol. 2011;178:1922-9.

Chauhan SK, Jin Y, Goyal S, Lee HS, Fuchslugar T, Lee HK, Dana R. A novel pro-lymphangiogenic function for Th17/IL17. Blood. 2011; 118:4630-4

Chen Y, Chauhan S, Lee HS, Saban D, Dana R. Chronic dry eye disease is principally mediated by effector memory Th17 cells. Mucosal Immunology 2014; 38-45. PMC3732510.

Chauhan SK, Saban DR, Dohlman TH, Dana R. CCL-21 conditioned Tregs induce allotolerance through enhanced homing to lymphoid tissue. J Immunol 2014; 192:817-23. PMC3947335.

Dohlman TH, Omoto M, Hua J, Stevenson W, Lee SM, Chauhan SK, Dana R. VEGF-trap aflibercept significantly improves long-term graft survival in high-risk corneal transplantation. Transplantation 2015; 99: 678-686. PMID25606789.

Tahvildari M, Omoto M, Chen Y, Emami P, Inomata T, Dohlman T, Kaye AE, Chauhan S, Dana R. In vivo expansion of regulatory T cells by low-dose interleukin-2 treatment increases allograft survival in corneal transplantation. Transplantation 2016; 100:525-32. PMID 26881788.

View Publications on Google Scholar >>

To learn more about Dr. Dana, read his "Meet a Specialist" profile here.

Education

Education

  • Johns Hopkins University, BA
  • Johns Hopkins University, MPH
  • Johns Hopkins University Medical School, M.D.
  • Health Care Management, Harvard University, MSc

Residency

  • Ophthalmology, University of Illinois, Illinois Eye and Ear Infirmary

Fellowship

  • Cornea, Wills Eye Hospital
  • Immunology, Schepens Eye Research Institute
  • Uveitis, Mass. Eye and Ear