Benjamin S. Bleier, M.D.

Assistant Professor of Otolaryngology, Harvard Medical School




Endoscopic Skull Base Surgery

Board Certification

  • Otolaryngology-Head and Neck Surgery

Main Campus
243 Charles Street
Boston, MA 02114
Phone: 617-573-6966
Fax: 617-573-3914
Monday, 8:30a.m.-4:30p.m. Thursday, 8:30a.m.- 4:30p.m.



Benjamin S. Bleier, M.D. is fellowship trained in complex sinus and endoscopic cranial base surgery and has authored over 40 peer-reviewed articles and book chapters in the field of sinus related disease. He lectures both nationally and internationally on the subjects of endoscopic management of sinus, orbit, and skull base tumors, cranial base reconstruction, and novel medical therapies for inflammatory sinus disease. He has also been recognized by the Michael J. Fox Foundation, Boston Magazine, Harvard Medicine Magazine, and The Scientist Magazine for his pioneering work in using the nasal lining to deliver drugs to brain.

Dr. Bleier is committed to providing only the highest quality patient care and focuses on revision and complex sinus surgery as well as state of the art endoscopic management of sinus, orbit, and cranial base lesions including tumors, cerebrospinal fluid (CSF) leaks, and encephaloceles.

Clinical Interests:
Revision and Complex Sinus Surgery
Endoscopic/Minimally Invasive Treatment of Sinus, Orbit, and Cranial Base Tumors, Cerebrospinal Fluid (CSF) Leaks, and Encephaloceles

Research Interests:
Transnasal Drug Delivery to the Brain
Novel Techniques in Endoscopic Orbital Surgery
Sutureless Laser Assisted Wound Repair
Novel Topical Therapies for Sinus Disease

Select Publications:
Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: a rabbit model. Bleier BS, Kofonow JM, Hashmi N, Chennupati SK, Cohen NA. Am J Rhinol Allergy. 2010 Mar-Apr;24(2):129-32

Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis. Bleier BS, Mulligan RM, Schlosser RJ. J Pharm Pharmacol. 2012 Mar;64(3):449-56. doi: 10.1111/j.2042-7158.2011.01409.x. Epub 2011 Nov 13.

P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X. Int Forum Allergy Rhinol. 2013 Mar 20. doi: 10.1002/alr.21166. [Epub ahead of print] PMID: 23520057

Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain. Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X. PLoS One. 2013 Apr 24;8(4):e61694. doi: 10.1371/journal.pone.0061694. Print 2013. PMID: 23637885

P-glycoprotein is a marker of tissue eosinophilia and radiographic inflammation in chronic rhinosinusitis without nasal polyps. Feldman RE, Lam AC, Sadow PM, Bleier BS. Int Forum Allergy Rhinol. 2013 May 15. doi: 10.1002/alr.21176. [Epub ahead of print] PMID: 23677641

View a complete list of publications on>>



  • University of Pennsylvania School of Medicine, M.D.


  • University of Pennsylvania School of Medicine


  • University of Pennsylvania School of Medicine, Head and Neck Surgery, Otolaryngology


  • Medical University of South Carolina, Rhinology and Endoscopic Skull Base Surgery