Benjamin S. Bleier, M.D.

Associate Professor of Otolaryngology, Harvard Medical School

Co-Director, Center for Thyroid Eye Disease and Orbital Surgery

Director, Endoscopic Skull Base Surgery




Endoscopic Skull Base Surgery

Board Certification

  • Otolaryngology-Head and Neck Surgery

Main Campus
243 Charles Street
Boston, MA 02114
Phone: 617-573-6966
Fax: 617-573-3914
Monday, 8:30a.m.-4:30p.m. Thursday, 8:30a.m.- 4:30p.m.



Dr. Benjamin S. Bleier, Associate Professor of Otolaryngology at Harvard Medical School, member of the Mass. Eye and Ear Sinus Center, and Co-Director of the Center for Thyroid Eye Disease and Orbital Surgery, is fellowship-trained in complex sinus and endoscopic cranial base surgery. Throughout his career, Dr. Bleier has helped pioneer several new minimally invasive approaches for orbital tumors and has authored more than 80 peer-reviewed articles and book chapters, as well as two textbooks in the field of orbit- and sinus-related disease. He lectures both nationally and internationally on topics including the endoscopic management of orbit and skull base tumors, endoscopic dacyrocystorhinostomy, causes and treatments of sinusitis, and intranasal drug delivery techniques to the brain. Dr. Bleier holds five patents and has been recognized by the Michael J. Fox Foundation, Boston Magazine, Harvard Medicine Magazine, and The Scientist Magazine for his work.

Dr. Bleier is committed to providing only the highest quality patient care and focuses on revision and complex sinus surgery as well as state of the art endoscopic management of sinus, orbit, and cranial base lesions including tumors, cerebrospinal fluid (CSF) leaks, and encephaloceles.

Clinical Interests

Revision and complex sinus surgery
Endoscopic/minimally invasive treatment of sinus, orbit, and cranial base tumors, cerebrospinal fluid (CSF) leaks, and encephaloceles

Research Interests

Transnasal drug delivery to the brain
Novel techniques in endoscopic orbital surgery
Sutureless laser assisted wound repair
Novel topical therapies for sinus disease


Select Publications

Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: A rabbit model. Bleier BS, Kofonow JM, Hashmi N, Chennupati SK, Cohen NA. Am J Rhinol Allergy. 2010 Mar–Apr;24(2):129–32.

Primary human sinonasal epithelial cell culture model for topical drug delivery in patients with chronic rhinosinusitis with nasal polyposis. Bleier BS, Mulligan RM, Schlosser RJ. J Pharm Pharmacol. 2012 Mar;64(3):449–56.

P-glycoprotein functions as an immunomodulator in healthy human primary nasal epithelial cells. Bleier BS, Nocera AL, Iqbal H, Hoang JD, Feldman RE, Han X. Int Forum Allergy Rhinol. 2013 Mar 20.

Permeabilization of the blood-brain barrier via mucosal engrafting: Implications for drug delivery to the brain. Bleier BS, Kohman RE, Feldman RE, Ramanlal S, Han X. PLoS One. 2013 Apr 24;8(4):e61694.

P-glycoprotein is a marker of tissue eosinophilia and radiographic inflammation in chronic rhinosinusitis without nasal polyps. Feldman RE, Lam AC, Sadow PM, Bleier BS. Int Forum Allergy Rhinol. 2013 May 15.

View a complete list of publications on »



  • University of Pennsylvania School of Medicine, M.D.


  • University of Pennsylvania School of Medicine


  • University of Pennsylvania School of Medicine, Head and Neck Surgery, Otolaryngology


  • Medical University of South Carolina, Rhinology and Endoscopic Skull Base Surgery