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Taha Jan, M.D.

Resident Taha Jan in lab coat

Originally from Slemani, Kurdistan, Dr. Taha Jan graduated summa cum laude with a bachelor's in molecular and cellular biology with honors from Vanderbilt University. As an undergraduate, he worked in the laboratory of Dr. Larry Zwiebel on the olfactory system and in the laboratory of Dr. Robert Waters investigating the somatosensory cortex and gustatory system. He then attended medical school at Stanford University School of Medicine, where he studied the role of the Wnt pathway in murine cochlear development under the tutelage of Dr. Alan Cheng. He spent an extra year as a Howard Hughes Medical Institutes research fellow while at Stanford to further pursue his research interests on cochlear development, stem cell biology, and regenerative medicine.

Dr. Jan completed his internship in general surgery at Mass General Hospital and is currently a Chief Resident in the Mass. Eye and Ear/Harvard Medical School Otolaryngology Residency Program. His work during residency has focused on the effects of secreted factors from human vestibular schwannomas on hearing loss in the Eaton-Peabody Laboratories as part of Dr. Tina Stankovic’s group. Dr. Jan’s research interests continue to include development of the inner ear and stem cell biology with the goal of ultimately translating discoveries in these areas into therapeutics for patients suffering from hearing and vestibular disorders.

Upon completion of his residency, Dr. Jan will be starting a fellowship at Stanford University in the Clinician Scientist Training Program in Otolaryngology.

For more information on Dr. Jan, check out his Harvard Catalyst website.

Education

Undergraduate School
Vanderbilt University (Molecular and Cellular Biology)

Medical School
Stanford University School of Medicine

FOCUS Project
Effects of secreted factors from human vestibular schwannomas on murine hair cells and spiral ganglion cells in vitro

Publications

Transient, afferent input-dependent, postnasal niche for neural progenitor cells in the cochlear nucleus. Volkenstein S, Oshima K, Sinkkonen ST, Corrales EC, Most SP, Chai R, Jan TA, van Amerongen R, Cheng AG, Heller S. Proceedings of the National Academy of Sciences USA. 2013 Aug 27. 110(35):14456-61.
PMID: 23940359

A simple method for purification of vestibular hair cells and non-sensory cells, and application for proteomic analysis. Herget M, Guo Z, Jan TA, Adams CM, Cheng AG, Heller S. PLoS ONE. 2013 Jun 4. 8(6):e66026.
PMID: 23750277

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Jan TA, Chai R, Sayyid ZN, van Amerongen R, Xia A, Wang T, Sinkkonen ST, Zeng YA, Levin JR, Heller S, Nusse R, Cheng AG. Development. 2013 Mar. 140(6):1196-1206. 

PMID: 23444352

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea. Chai R, Kuo B, Wang T, Liaw EJ, Xia A, Jan TA, Liu Z, Taketo MM, Oghalai JS, Nusse R, Zuo J, Cheng AG. Proc Natl Acad Sci U S A. 2012 May 22. 109(21):8167-72. doi: 10.1073/pnas.1202774109. Epub 2012 May 4.
PMID: 22562792 

Isolating LacZ-expressing cells from mouse inner ear tissues using flow cytometry. Jan TA, Chai R, Sayyid ZN, Cheng AG. J Vis Exp. 2011 Dec 23. (58):e3432. doi: 10.3791/3432.
PMID: 22217925

Intrinsic regenerative potential of murine cochlear supporting cells. Sinkkonen ST, Chai R, Jan TA, Hartman BH, Laske R, Gahlen F, Sinkkonen W, Cheng AG, Oshima K, Heller S. Scientific Reports. 2011 Jun 29. 1:26.
PMID: 22355545 

Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea. Chai R, Xia A, Wang T, Jan TA, Hayashi T, Bermingha-McDonogh O, Cheng AG. Journal of the Association for Research in Otolaryngology. 2011 April 7. 12(4):455-69.
PMID: 21472479 

Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. Narsinh K, Lee A, Sun N, Almeida P, Hu S, Jan TA, Wilson K, Leong D, Rosenberg J, Yao M, Wu J. Journal of Clinical Investigation. 2011 Mar 1. 121(3):1217-21.
PMID: 21317531 

Genetic analysis of tongue size and taste papillae number and size in recombinant inbred strains of mice. Reiner DJ, Jan TA, Boughter JD, Li CX, Lu L, Williams RW, Waters RS. Chemical Senses. 2008 Oct. 33(8):693-707.
PMID: 18653645 

A functional role for Anopheles gambiae arrestin1 in olfactory signal transduction. Walker WB, Smith EM, Jan TA, Zwiebel LJ. Journal of Insect Physiology. 2008 Apr. 54(4):680-90.
PMID: 18328499 

Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice. Jan TA, Lu L, Li CX, Williams RW, Waters RS. BMC Neuroscience. 2008 Jan 7. vol 9:article #3.
PMID: 18179704 

Early postnatal alcohol exposure reduced the size of vibrissal barrel field in rat somatosensory cortex (SI) but did not disrupt barrel field organization. Oladehin A, Margret CP, Maier SE, Li CX, Jan TA, Chappell TD, Waters RS. Alcohol. 2007 Jun. 41(4):253-61.
PMID: 17630086 

Prenatal alcohol exposure (PAE) reduces the size of the forepaw representation in forepaw barrel subfield (FBS) cortex in neonatal rats: Relationship between periphery and central representation. Margret CP, Chappell TD, Li CX, Jan TA, Matta SG, Elberger AJ, Waters RS. Experimental Brain Research. 2006 Jul. 172(3):387-96.
PMID: 16424976